Immune cells in liver regeneration

Na Li _ and Jinlian Hua

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Oncotarget. 2017; 8:3628-3639. https://doi.org/10.18632/oncotarget.12275

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Na Li1 and Jinlian Hua1

1 College of Veterinary Medicine, Shaanxi Center of Stem Cells Engineering & Technology, Northwest A&F University, Yangling, Shaanxi, China

Correspondence to:

Jinlian Hua, email:

Keywords: liver, partial hepatectomy, regeneration, innate immune system, adaptive immune system

Received: July 27, 2016 Accepted: September 22, 2016 Published: September 27, 2016


After partial hepatectomy, hepatocytes proliferate to restore mass and function of the liver. Macrophages, natural killer (NK) cells, natural killer T (NKT) cells, dendritic cells (DC), eosinophils, gamma delta T (γδT) cells, and conventional T cells, as well as other subsets of the immune cells residing in the liver control liver regeneration, either through direct interactions with hepatocytes or indirectly by releasing inflammatory cytokines. Here, we review recent progress regarding the immune cells in the liver and their functions during liver regeneration.

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