Clinical Research Papers:

Low-dose green tea intake reduces incidence of atrial fibrillation in a Chinese population

Dong-Chen Liu, Jian-Jun Yan, You-Nan Wang, Ze-Mu Wang, Zhi-Yong Xie, Yao Ma, Yang Yang, Li Yang and Lian-Sheng Wang _

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Oncotarget. 2016; 7:85592-85602. https://doi.org/10.18632/oncotarget.12243

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Dong-Chen Liu1,*, Jian-Jun Yan1,*, You-Nan Wang2,*, Ze-Mu Wang1, Zhi-Yong Xie1, Yao Ma1, Yang Yang1, Li Yang2 and Lian-Sheng Wang1

1 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

2 Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

* These authors have contributed equally to this work

Correspondence to:

Lian-Sheng Wang, email:

Keywords: green tea; atrial fibrillation; Chinese; case control; low-dose

Received: May 05, 2016 Accepted: September 20, 2016 Published: September 24, 2016


The aim of the present study was to assessthe association between green tea intake and incidence of atrial fibrillation (AF) in a Chinese population. A total of 801 (mean age: 62 years; 56% male) subjects were enrolled: 401 AF patients and 400 controls. All subjects completed a questionnaire and the associations between their green tea drinking habits and incidence of AF were assessed using the odds ratio (OR) and binary logistic regression. After multivariate adjustment, green tea intake presented as a protective factor against the incidence of AF (OR: 0.349, 95% CI: 0.253-0.483, P < 0.001). The green tea protection showed downward trend with increasing green tea intake (P for the trend= 0.001). Low frequency, low concentration, short-term tea consumption was classified as low-dose green tea intake. Green tea intake decreased the incidence of both paroxysmal AF (OR: 0.307, 95% CI: 0.216-0.436, P < 0.001) and persistent AF (OR: 0.355, 95% CI: 0.261-0.482, P < 0.001) and may be associated with a decreased incidence of AF. This study suggests that low-dose green tea intake strongly protects against AF.

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