Research Papers: Gerotarget (Focus on Aging):

Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice

Xi Chen, Lihui Li, Jianmin Guo, Lingli Zhang, Yu Yuan, Binglin Chen, Zhongguang Sun, Jiake Xu and Jun Zou _

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Oncotarget. 2016; 7:71072-71086. https://doi.org/10.18632/oncotarget.12125

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Xi Chen1,2,3, Lihui Li1, Jianmin Guo1, Lingli Zhang1, Yu Yuan1, Binglin Chen1, Zhongguang Sun1, Jiake Xu1,3 and Jun Zou1

1 School of Kinesiology, Shanghai University of Sport, Shanghai, P. R. China

2 School of Sports Science, Wenzhou Medical University, Wenzhou, P. R. China

3 School of Pathology and Laboratory Medicine, The University of Western Australia, Western Australia, Australia

Correspondence to:

Jun Zou, email:

Keywords: exercise; osteoporosis; Wnt signaling pathway; SAMP6; senile; Gerotarget

Received: May 08, 2016 Accepted: September 02, 2016 Published: September 19, 2016


This study examined the effects of different exercise intensities and durations on bone mineral density (BMD) and bone strength in senescence-accelerated mouse prone 6 (SAMP6) and determined the involvement of the Wnt signaling pathway in exercise-induced osteogenesis. Three-month-old male SAMP6 mice were randomly assigned to different speeds of treadmill running exercise representing low, medium and high intensity, with the duration of five and nine weeks, respectively. We showed that medium-intensity exercise had positive effects on skeletal health, including BMD and bone strength, and the efficacy was higher than that of low-intensity exercise. Interestingly, high-intensity exercise can maintain or even increase bone strength, despite its negative effects on bone mass. Nine weeks of exercise was superior to 5 weeks of exercise, particularly for low-intensity exercise. Furthermore, these effects of exercise-induced osteogenesis are accompanied by activation of the Wnt signaling pathway. Taken together, these results suggest that the positive effects of exercise on osteoporosis prevention are intensity and duration-dependent, and may involve the regulation of Wnt signaling pathways.

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