Oncotarget

Reviews:

Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy

Hanmin Li and Lisheng Zhang _

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:1805-1813. https://doi.org/10.18632/oncotarget.12101

Metrics: PDF 4194 views  |   HTML 4567 views  |   ?  


Abstract

Hanmin Li1 and Lisheng Zhang2

1 Hepatic Disease Institute, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, People’s Republic of China

2 College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People’s Republic of China

Correspondence to:

Hanmin Li, email:

Lisheng Zhang, email:

Keywords: liver regeneration; hepatocellular carcinoma; immunity; inflammation; vasculature

Received: January 07, 2016 Accepted: September 12, 2016 Published: September 17, 2016

Abstract

Research on liver cancer prevention and treatment has mainly focused on the liver cancer cells themselves. Currently, liver cancers are no longer viewed as only collections of genetically altered cells but as aberrant organs with a plastic stroma, matrix, and vasculature. Improving the microenvironment of the liver to promote liver regeneration and repair by affecting immune function, inflammation and vasculature can regulate the dynamic imbalance between normal liver regeneration and repair and abnormal liver regeneration, thus improving the microenvironment of liver regeneration for the prevention and treatment of liver cancer. This review addresses the basic theory of the liver regeneration microenvironment, including the latest findings on immunity, inflammation and vasculature. Attention is given to the potential design of molecular targets in the microenvironment of hepatocellular carcinoma (HCC). In an effort to improve the liver regeneration microenvironment of HCC, researchers have extensively utilized the enhancement of immunity, anti-inflammation and the vasculature niche, which are discussed in detail in this review. In addition, the authors summarize the latest pro-fibrotic transition characteristics of the vascular niche and review potential cell therapies for liver disease.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 12101