Review: Traumatic brain injury and hyperglycemia, a potentially modifiable risk factor

Jia Shi, Bo Dong, Yumin Mao, Wei Guan, Jiachao Cao, Rongxing Zhu and Suinuan Wang _

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Oncotarget. 2016; 7:71052-71061. https://doi.org/10.18632/oncotarget.11958

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Jia Shi1,*, Bo Dong1,*, Yumin Mao1, Wei Guan1, Jiachao Cao1, Rongxing Zhu1 and Suinuan Wang1

1 Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China

* These authors have contributed equally to this work

Correspondence to:

Suinuan Wang, email:

Keywords: hyperglycemia, traumatic brain injury, blood glucose, glycemic control

Received: May 27, 2016 Accepted: September 02, 2016 Published: September 10, 2016


Hyperglycemia after severe traumatic brain injury (TBI) occurs frequently and is associated with poor clinical outcome and increased mortality. In this review, we highlight the mechanisms that lead to hyperglycemia and discuss how they may contribute to poor outcomes in patients with severe TBI. Moreover, we systematically review the proper management of hyperglycemia after TBI, covering topics such as nutritional support, glucose control, moderated hypothermia, naloxone, and mannitol treatment. However, to date, an optimal and safe glycemic target range has not been determined, and may not be safe to implement among TBI patients. Therefore, there is a mandate to explore a reasonable glycemic target range that can facilitate recovery after severe TBI.

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