Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

Yongxiang Shi; Weishan Chen; Qinghuai Li; Zhaoming Ye

doi:10.18632/oncotarget.11902

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

This article has been retracted. Retraction in: Oncotarget. 2017; 8:34019.

Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

Yongxiang Shi, Weishan Chen, Qinghuai Li and Zhaoming Ye _

PDF | HTML | How to cite

Oncotarget. 2016; 7:68151-68155. https://doi.org/10.18632/oncotarget.11902

Metrics: PDF 1674 views | HTML 2433 views | ?

Abstract

Yongxiang Shi1, Weishan Chen1, Qinghuai Li2, Zhaoming Ye1

1Department of Orthopaedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

2Department of Medicine, 3rd Hospital of Henan Province, Henan, China

Correspondence to:

Zhaoming Ye, email: [email protected]

Keywords: osteosarcoma, papillary thyroid cancer, AR, repeat, CAG

Received: May 24, 2016 Accepted: August 13, 2016 Published: September 08, 2016

ABSTRACT

The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we conducted two case-control studies in a Chinese population to investigate the possible relationship between these two AR repeat polymorphisms and the risk of PTC and Osteosarcoma. The AR CAG repeat length was significantly associated with both risk of PTC and Osteosarcoma. Subjects with shorter AR CAG repeats had a higher risk of developing PTC (OR = 1.47, 95% CI: 1.17–1.85, P = 0.001) and Osteosarcoma (OR = 1.53, 95% CI: 1.19–1.97, P = 9.2 x 10^–4). Specifically, shorter GGN repeats also contribute a significant increased risk of Osteosarcoma (OR = 1.35, 95% CI: 1.03–1.77, P = 0.030). Our results contribute to a better understanding of the complex hormone related mechanisms underlying PTC and Osteosarcoma.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 11902

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

Abstract