Research Papers:

The clinicopathological and prognostic features of Chinese and Japanese inpatients with lung cancer

Yang Gao, Ji-feng Zhang, Jia-jie Liu, Li-li Liu, Xue-feng Yang, Hua-mao Jiang and Hua-chuan Zheng _

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Oncotarget. 2016; 7:67425-67434. https://doi.org/10.18632/oncotarget.11850

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Yang Gao1,*, Ji-feng Zhang1,*, Qing-chang Li2, Jia-jie Liu1, Li-li Liu1, Xue-feng Yang1, Hua-mao Jiang3, Hua-chuan Zheng1,4

1Cancer Center, Key Laboratory of Brain and Spinal Cord Injury of Liaoning Province, and Animal Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China

2Department of Pathology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China

3Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China

4Life Science Institute of Jinzhou Medical University, Jinzhou 121001, China

*These authors have contributed equally to this work

Correspondence to:

Hua-chuan Zheng, email: [email protected]

Keywords: lung cancer, clinicopathological behaviors, prognosis, China, Japan

Received: May 29, 2016    Accepted: August 21, 2016    Published: September 06, 2016


Here, we retrospectively compared the differences in clinicopathological behaviors and prognosis of lung cancer from the First Affiliated Hospital (CMU1, n=513), Shengjing Hospital (CMUS, n=1021), Tumor Hospital (CMUT, n=5378) of China Medical University, the First Affiliated Hospital of Dalian (DMU, n=2251) and Jinzhou (JMU, n=630) Medical University, Takaoka Kouseiren Hospital (Takaoka, n=163) of Japan. Japanese lung cancer patients showed smaller tumor size, lower TNM staging, lower ratio of squamous cell carcinoma and higher ratio of small and large cell carcinomas than Chinese patients (p<0.05). Survival analysis showed that tumor size was employed as a prognostic factor for the Japanese and Chinese cancer patients (p<0.05). In DMU and CMUS, the ratios of female patients or adenocarcinoma were higher than other hospitals (p<0.05), while the patients from CMUT and CMU1 were younger than the others (p<0.05). The ratios of squamous cell carcinoma from CMUT, CMU1 and JMU were higher than the others, while it was the same for the ratio of large and small cell carcinoma in Takaoka and CMU1 (p<0.05). TNM staging was higher in CMUT than JMU and Takaoka (p<0.05). The female patients of lung cancer showed young prone, large tumor size, a high ratio of adenocarcinoma and advanced TNM staging in comparison to the counterpart (p<0.05). The younger patients of lung cancer displayed smaller tumor size, higher ratio of adenocarcinoma, lower TNM staging than the elder in Takaoka (p<0.05). There were more aggressive behaviors and shorter survival time for Chinese than Japanese lung cancer patients. The prevention of lung cancer should be strengthened by establishing a systematic and effective screening strategy, especially for the young and female patients.

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