Research Papers:

Abstract

Glioma, which is a rare and highly fatal brain cancer, has been studied for many decades. However, only a few etiological factors have been established. Genetic factors play an essential roles in the development of gliomas and are key component of preventive oncology. However, only a small proportion of the genetic effect has been yet established. In current study, we systematically evaluated whether genetic variants of CART gene, which generates multiple biologically active peptides, contribute to susceptibility of gliomas among Chinese people with a two-stage, case–control study. In stage I, we found rs2239670 (Allele A vs G: OR = 1.33; 95% CI = 1.03-1.70; P = 0.026) and rs11575893 (Allele T vs C: OR = 1.29; 95% CI = 1.01-1.65; P = 0.040) were significantly associated with increased glioma susceptibility. Then the two SNPs were significantly replicated in an independent stage. When pooled together, both rs2239670 (Allele A vs G: OR = 1.27; 95% CI = 1.10-1.46; P = 0.001) and rs11575893 (Allele T vs C: OR = 1.25; 95% CI = 1.09-1.45; P = 0.002) were significant associated with increased glioma susceptibility. Our data suggest that the genetic variants in the CART gene potentially predispose their carriers to gliomas.