Oncotarget

Research Papers:

Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma

Guannan Wang, Suling Xu, Chao Cao, Jing Dong, Yudong Chu, Guijuan He and Zhiwei Xu _

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Oncotarget. 2016; 7:62598-62606. https://doi.org/10.18632/oncotarget.11545

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Abstract

Guannan Wang1,2,*, Suling Xu3,4,*, Chao Cao5, Jing Dong2, Yudong Chu6, Guijuan He1, Zhiwei Xu7

1Academy of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China

2Blood Purification Center, Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo 315041, China

3Department of Dermatology, Affiliated Hospital of Medical College, Ningbo University, Ningbo 315020, China

4Department of Dermatology, Ningbo First Hospital, Ningbo University, Ningbo 315010, China

5Department of Respiratory Medicine, Ningbo First Hospital, Ningbo University, Ningbo 315010, China

6Department of Nephrology, Ningbo Medical Center, Lihuili Eastern Hospital, Ningbo 315040, China

7Department of Critical Care Medicine, Ningbo Medical Center, Lihuili Eastern Hospital, Ningbo 315040, China

*These authors have contributed equally to this work

Correspondence to:

Zhiwei Xu, email: [email protected]

Guijuan He, email: [email protected]

Keywords: glioma, eczema, meta-analysis

Received: March 05, 2016     Accepted: August 09, 2016     Published: August 23, 2016

ABSTRACT

We investigated the relationship between eczema and the risk of primary glioma. Relevant studies were selected through electronic searches of PubMed and EMBASE. A meta-analysis of 12 case-control studies and one cohort study was performed. A fixed effect model was applied to analyze 13 studies consisting of 10,897 glioma cases and 56,081 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the associations. The data demonstrate that eczema significantly reduces the risk of glioma (OR = 0.69, 95% CI = 0.61–0.78, P < 0.001). Additional studies with larger patient cohorts are required to validate our findings.


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