Research Papers:

Pesticide exposure and risk of bladder cancer: A meta-analysis

Zhen Liang, Xiao Wang, Bo Xie, Yi Zhu, Jian Wu, Shiqi Li, Shuai Meng, Xiangyi Zheng, Alin Ji _ and Liping Xie

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Oncotarget. 2016; 7:66959-66969. https://doi.org/10.18632/oncotarget.11397

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Zhen Liang1,*, Xiao Wang1,*, Bo Xie2, Yi Zhu1, Jian Wu1, Shiqi Li1, Shuai Meng1, Xiangyi Zheng1, Alin Ji3, Liping Xie1

1Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China

2Department of Urology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, People’s Republic of China

3Department of Urology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Alin Ji, email: [email protected]

Keywords: pesticide exposure, bladder cancer, meta-analysis, epidemiology

Received: September 22, 2015    Accepted: August 08, 2016    Published: August 19, 2016


Objective We conducted a meta-analysis to quantitatively evaluate the correlation between pesticide exposure and the risk of bladder cancer by summarizing the results of published case-control and cohort studies.

Methods A systematic literature search of articles update to February 2015 was conducted via Pubmed, Web of Science, Cochrane Library, and the Chinese National Knowledge Infrastructure (CNKI) databases, and the references of the retrieved articles. Fixed- or random-effect models were used to summarize the estimates of OR with 95% CIs for the highest versus the lowest exposure of pesticide.

Results The pooled OR estimates indicated that pesticide exposure was associated with an increased risk of bladder cancer (OR=1.649, 95% CI 1.223-2.223). In subgroup analysis, we detected pesticide exposure demonstrated as a significant risk factor on bladder cancer in America (OR=1.741, 95% CI 1.270-2.388). Similar results were discovered in both case-control group and cohort group (OR=2.075, 95% CI 1.183-3.638, OR=1.146, 95% CI 1.074-1.223, respectively). No evidence of publication bias was found by Begg’s or Egger’s test (P = 0.210, P = 0.358, respectively).

Conclusion In conclusion, our meta-analysis indicated that pesticide exposure was associated with an increased risk of bladder cancer. Further researches should be conducted to confirm the findings in our study and better clarify the potential biological mechanisms.

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