Clinical Research Papers:
Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results
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Francesca De Felice1, Daniela Musio1, Giovanni Luca Gravina2, Francesco Marampon2 and Vincenzo Tombolini1,3
1 Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy
2 Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L’Aquila, L’Aquila, Italy
3 Spencer-Lorillard Foundation, Viale Regina Elena, Rome, Italy
Correspondence to:
Francesca De Felice, email:
Keywords: radiotherapy; stage I seminoma; surveillance; chemotherapy; orchiectomy
Received: May 22, 2016 Accepted: August 13, 2016 Published: August 18, 2016
Abstract
Aim: To report long term oncologic outcomes after adjuvant radiotherapy (RT) for stage I seminoma.
Method: We reviewed the complete data set for all patients treated at our institute between 1988 and 2005 for stage I seminoma with adjuvant RT after radical orchiectomy .
Results: A total of 85 patients were included. The median follow-up was 15 years. The 20-year overall survival (OS) and relapse free survival (RFS) were 92% and 96.3%, respectively. No severe acute and late complications were recorded. Overall 5.9% of patients had a second unrelated malignancy.
Conclusion: Adjuvant RT is an efficacious and safe treatment in stage I seminoma.