The emerging role of miR-506 in cancer
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Jian Li1, Jingfang Ju2, Bing Ni3 and Huaizhi Wang1
1 Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, PR China
2 Translational Research Laboratory, Department of Pathology, Stony Brook University, Stony Brook, NY, USA
3 Department of Pathophysiology and High Altitude Pathology, Third Military Medical University, Chongqing, PR China
Huaizhi Wang, email:
Bing Ni, email:
Jingfang Ju, email:
Keywords: microRNAs; miR-506; cancer; tumor suppressor
Received: April 06, 2016 Accepted: August 10, 2016 Published: August 15, 2016
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. They are involved in almost all biological processes, and many have been identified as potential oncogenes or tumor suppressor genes. miR-506 was recently discovered to play pivotal roles in regulating cell proliferation, differentiation, migration and invasion. Dysregulation of miR-506 has been demonstrated in multiple types of cancers; however, whether it functions as an oncogene or a tumor suppressor seems to be context-dependent. Altered miR-506 expression in cancer is caused by promoter methylation and changes in upstream transcription factors. In this review, we summarize the current understanding of the diverse roles and underlying mechanisms of miR-506 and its involvement in cancer, and suggest the potential therapeutic strategy based on miR-506.
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