Oncotarget

Research Papers:

DcR3 gene polymorphisms are associated with sporadic breast infiltrating ductal carcinoma in Northeast Chinese women

Zhenkun Fu, Shuang Chen, Shengwei Liu, Shaoli Han, Xiang Gao, Dalin Li and Dianjun Li _

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Oncotarget. 2016; 7:57970-57977. https://doi.org/10.18632/oncotarget.11153

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Abstract

Zhenkun Fu1,*, Shuang Chen1,2,*, Shengwei Liu2, Shaoli Han2, Xiang Gao2, Dalin Li3, Dianjun Li1,2

1Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China

2Department of Immunology, Harbin Medical University and Heilongjiang Academy of Medical Science, 150081 Harbin, China

3Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, 150081 Harbin, China

*Co-first author

Correspondence to:

Dianjun Li, email: [email protected]

Dalin Li, email: [email protected]

Keywords: DcR3, TNFRSF6β, breast infiltrating ductal carcinoma, single nucleotide polymorphism, haplotype

Received: October 28, 2015     Accepted: July 26, 2016     Published: August 09, 2016

ABSTRACT

Decoy Receptor 3 (DcR3), also called TNFRSF6β, is a member of the tumor necrosis factor receptor superfamily and is a soluble receptor for FasL. DcR3 is overexpressed in cancers and contributes to tumorigenesis through immune suppression and promotion of angiogenesis. We found that DcR3 is overexpressed in breast infiltrating ductal carcinoma (IDC) cells as compared with normal controls. We also conducted a case-control study analyzing associations of DcR3 polymorphisms with breast IDC risk. Subjects included 531 females with breast IDC and 592 age-matched healthy controls. Four DcR3 single nucleotide polymorphism loci with minor frequencies of more than 5% (rs3208008, rs41309931, rs2297441 and rs1291207) were genotyped using polymerase chain reaction restriction fragment length polymorphism and sequencing. Our results revealed significant differences in rs41309931genotypes and alleles (P < 0.01). Based on Haploview software analysis, the haplotype block Ars3208008 Grs41309931 Grs2297441 Ars1291207 exhibited the highest frequency, but, haplotype blocks Ars3208008 Trs41309931 Grs2297441 Ars1291207 and Crs3208008 Grs41309931 Grs2297441 Ars1291207 were associated with breast IDC risk. This study also detected associations between DcR3 gene polymorphisms and the clinicopathological features of breast IDC, including lymph node metastasis and C-erbB2, P53, estrogen receptor and progesterone receptor status. These data indicate that DcR3 gene polymorphisms are associated with sporadic breast IDC risk in Northeast Chinese females.


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