Oncotarget

Research Papers:

Cumulative score based on preoperative plasma fibrinogen and serum C-reactive protein could predict long-term survival for esophageal squamous cell carcinoma

Rui Tian, Hong Yan, Fei Zhang, Peng Sun, Ai-Ran Wu, Min Zhang, Yu-Lu Jiang, Jing Wu, Yan-Hong Lu, Qiu-Yan Xu, Xiao-Hong Zhan, Rong-Xin Zhang, Li-Ting Qian _ and Jie He

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Oncotarget. 2016; 7:61533-61543. https://doi.org/10.18632/oncotarget.11145

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Abstract

Rui Tian1,*, Hong Yan1,*, Fei Zhang2,3,4, Peng Sun2,3,4, Ai-Ran Wu1, Min Zhang1, Yu-Lu Jiang1, Jing Wu1, Yan-Hong Lu5, Qiu-Yan Xu1, Xiao-Hong Zhan1, Rong-Xin Zhang5, Li-Ting Qian6, Jie He1

1Department of Pathology, Anhui Cancer Hospital & Anhui Provincial Hospital Affiliated Anhui Medical University, Hefei, Anhui, P. R. China

2Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China

3State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, P. R. China

4Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P. R. China

5Department of Thoracic Surgery, Anhui Cancer Hospital & Anhui Provincial Hospital Affiliated Anhui Medical University, Hefei, Anhui, P. R. China

6Department of Radiology, Anhui Provincial Hospital & Anhui Provincial Hospital Affiliated Anhui Medical University, Hefei, Anhui, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Li-Ting Qian, email: [email protected]

Jie He, email: [email protected]

Keywords: esophageal squamous cell carcinoma, fibrinogen, C-reactive protein, survival

Received: April 13, 2016    Accepted: July 27, 2016    Published: August 09, 2016

ABSTRACT

The present study was to establish a prognostic indicator based on preoperative fibrinogen and C-reactive protein (CRP) (FC score) in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative plasma fibrinogen and serum CRP levels were reviewed in patients who underwent transthoracic esophagectomy. The optimal cut-off value for fibrinogen and CRP was defined as 4.0 g/dL and 10.0 mg/L according to previous reports. Patients with elevated fibrinogen and CRP levels were assigned a score of 2, those with only one of these two abnormalities were allocated a score of 1, and those with neither of the two abnormalities were assigned a score of 0. Preoperative FC score was significantly correlated with degree of differentiation, depth of invasion, tumor-node-metastasis (TNM) stage and modified Glasgow Prognostic Score (mGPS). No significant differences in age, gender, tumor length, tumor location, lymph node status or smoking were identified between groups. Univariate survival analysis demonstrated that high preoperative FC score (1/2) was significantly associated with impaired disease free survival (DFS) [hazard ratio (HR), 1.650; 95% confidence interval (CI), 1.181-2.303; P=0.003] and overall survival (OS) (HR, 1.879; 95% CI, 1.333-2.648; P<0.001), and it remained an independent predictor for both DFS (HR, 1.468; 95% CI, 1.043-2.067; P=0.028) and OS (HR, 2.070; 95% CI, 1.266-3.385; P=0.004) in multivariate Cox regression analysis. Preoperative FC score might represent a new potential marker of worst prognosis that warrants further evaluation in prospective and large cohort studies among ESCC patients who underwent transthoracic esophagectomy.


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