Oncotarget

Research Papers:

LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells

Qian Liu, Xu Guo, Shengshun Que, Xi Yang, Hongxia Fan, Min Liu, Xin Li and Hua Tang _

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Oncotarget. 2017; 8:43768-43781. https://doi.org/10.18632/oncotarget.10844

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Abstract

Qian Liu1,*, Xu Guo1,*, Shengshun Que1,*, Xi Yang1, Hongxia Fan1, Min Liu1, Xin Li1 and Hua Tang1

1Tianjin Life Science Research Center, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

*These authors have contributed equally to this work

Correspondence to:

Hua Tang, email: [email protected]

Keywords: ceRNA, miRNA, Let-7, N-myc, lnc-RNA

Received: December 13, 2015    Accepted: June 17, 2016    Published: July 26, 2016

ABSTRACT

Long non-coding RNAs (lncRNAs) can regulate gene expression at different levels and are widely participate in various physiological and pathological processes. Emerging evidences suggests that a number of differentially expressed lncRNAs are involved in tumorigenesis. However, the function and expression regulation of a vast majority of these unique RNAs is little known. Here, we found that the lncRNA Ras suppressor protein 1 pseudogene 2 (RSU1P2) is upregulateded in cervical cancer tissues and has a tumour-promoting role. We revealed that RSU1P2 acts as a competitive endogenous RNA (ceRNA) through regulating the expression of IGF1R, N-myc and EphA4. The mechanism of this regulation is via competition for the shared microRNA let-7a. This competition promotes the malignant phenotype of cervical carcinoma cells. The transcription factor N-myc forms a positive feedback loop with RSU1P2 by in turn activating its expression, thereby enhancing its oncogenic capacity. Hence, cancer-selective targeting of RSU1P2 could have strong benefits.


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