Oncotarget

Clinical Research Papers:

Clinical utility of microRNA-378 as early diagnostic biomarker of human cancers: a meta-analysis of diagnostic test

Zhan-Zhan Li, Liang-Fang Shen, Yan-Yan Li, Peng Chen and Li-Zhang Chen _

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Oncotarget. 2016; 7:58569-58578. https://doi.org/10.18632/oncotarget.10707

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Abstract

Zhan-Zhan Li1, Liang-Fang Shen1, Yan-Yan Li2, Peng Chen3, Li-Zhang Chen4

1Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China

2Department of Nursing, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China

3Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China

4Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province 410078, China

Correspondence to:

Li-Zhang Chen, email: [email protected]

Keywords: cancer, microRNA-378, early diagnosis, meta-analysis, tumor marker

Received: April 12, 2016     Accepted: June 06, 2016     Published: July 19, 2016

ABSTRACT

A meta-analysis was performed to evaluate the diagnostic value of miR-378 for detecting human cancers. Systematic electronic searches were conducted in PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang from the inception to January 15, 2016. We used the bivariate mixed effects models to estimate the combined sensitivity, specificity, PLRs (positive likelihood ratios), NLR (negative likelihood ratios), DORs (diagnostic odds ratios) and their 95% CI (confidence intervals) for assessing the diagnostic performance of miR-378 for cancers. Twelve studies were included in the meta-analysis, with a total number of 1172 cancer patients and 809 health controls. The overall estimated sensitivity and specificity were 0.75 and 0.74. The pooled PLR was 2.91, NLR was 0.34, DOR was 8.50, and AUC (Area Under the Curve) was 0.81. The subgroup analyses suggested that AUC for plasma-based is higher than serum-based. The overall diagnostic values of miR-378 in the present meta-analyses are moderate accurate for human cancers; The source of specimen has an effect on the diagnostic accuracy. The diagnostic value of serum-based was higher than that of plasma-based.


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