Oncotarget

Clinical Research Papers:

Increased expression of αTubulin is associated with poor prognosis in patients with pancreatic cancer after surgical resection

Chao Lin, Guo-chao Zhao, Ya-dong Xu, Dan-song Wang, Da-yong Jin, Yuan Ji, Wen-hui Lou and Wen-chuan Wu _

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Oncotarget. 2016; 7:60657-60664. https://doi.org/10.18632/oncotarget.10630

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Abstract

Chao Lin1, Guo-chao Zhao1, Ya-dong Xu1, Dan-song Wang1, Da-yong Jin1, Yuan Ji2, Wen-hui Lou1, Wen-chuan Wu1

1Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

2Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China

Correspondence to:

Wen-chuan Wu, email: wuwenchuan1973@126.com

Wen-hui Lou, email: lou.wenhui@zs-hospital.sh.cn

Keywords: pancreatic cancer, αTubulin, overall survival, prognostic biomarker, nomogram

Received: February 17, 2016     Accepted: June 07, 2016     Published: July 16, 2016

ABSTRACT

Background: αTubulin, the essential orchestrator of cytoskeletal protein polymers, critical for cell growth and division, motility, signaling development and maintenance of cell shape, plays vital roles in the oncogenesis and progression of various types of cancer, but its role in prognosis of pancreatic cancer patients remains unknown. The aim of this study was to investigate its prognostic value in patients with pancreatic cancer after surgical resection.

Results: αTubulin expression in pancreatic cancer was significantly associated with N classification (p = 0.013) and TNM stage (p = 0.025). Increased expression of αTubulin in tumoral tissue was associated with decreased overall survival rate (p = 0.002). Multivariate Cox regression analysis suggested that αTubulin expression was an independent prognostic indicator for pancreatic cancer except for T and N classification (p = 0.002). Using multivariate analysis, αTubulin expression, CA19-9, and N classification were selected to generate the nomogram to predict the 1-year and 3-year overall survival. The c-index of this model was 0.692. The calibration curve for probability of survival showed good agreement between prediction by nomogram and actual observation.

Methods: αTubulin expression was evaluated by tissue microarrays from 124 pancreatic cancer patients and statistically assessed for correlations with the clinical profiles and the prognosis of the patients with pancreatic cancer. The prognostic nomogram was designed to predict 1-year and 3-year overall survival probability.

Conclusions: αTubulin expression might be an independent prognostic factor for pancreatic cancer after surgical resection and could potentially be a high-priority therapeutic target. Incorporating αTubulin expression into CA19-9 and N classification can provide a good prognostic model.


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