Oncotarget

Research Papers:

Prognostic impact of MYH9 expression on patients with acute myeloid leukemia

Mengxia Yu, Jinghan Wang, Zhijuan Zhu, Chao Hu, Qiuling Ma, Xia Li, Xiufeng Yin, Jiansong Huang, Ting Zhang, Zhixin Ma, Yile Zhou, Chenying Li, Feifei Chen, Jian Chen, Yungui Wang, Hanzhang Pan, Dongmei Wang and Jie Jin _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2017; 8:156-163. https://doi.org/10.18632/oncotarget.10613

Metrics: PDF 3006 views  |   HTML 3084 views  |   ?  


Abstract

Mengxia Yu1,2,3,*, Jinghan Wang1,2,3,*, Zhijuan Zhu1,2,3,4,*, Chao Hu1,2,3, Qiuling Ma1,2,3,5, Xia Li1,2,3, Xiufeng Yin1,2,3, Jiansong Huang1,2,3, Ting Zhang1,2,3, Zhixin Ma1,2,3, Yile Zhou1,2,3, Chenying Li1,2,3, Feifei Chen1,2,3, Jian Chen1,2,3, Yungui Wang1,2,3, Hanzhang Pan1,2,3, Dongmei Wang1,2,3, Jie Jin1,2,3

1Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China

2Institute of Hematology, Zhejiang University, Hangzhou, China

3Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China

4Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China

5Department of Hematology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China

*These authors are contributed equally to this work

Correspondence to:

Jie Jin, email: [email protected]

Keywords: MYH9, acute myeloid leukemia, prognosis

Received: March 14, 2016     Accepted: May 10, 2016     Published: July 15, 2016

ABSTRACT

MYH9 expression has previously been demonstrated as an independent predictor of clinical outcome in solid tumors. However, the prognostic relevance of MYH9 expression in acute myeloid leukemia is still unclear. Here, we found high MYH9 expressers were seen more frequently in females and more frequently in M4 morphology. We also found high MYH9 expressers had lower percentage of bone marrow blasts. In addition, overexpression of MYH9 was associated with an inferior overall survival. Notably, distinct microRNA signatures were seen in high MYH9 expressers. These results were also validated in an independent cohort of AML patients using the published data. In conclusion, gene of MYH9 expression might serve as a reliable predictor for overall survival in AML patients.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 10613