Oncotarget

Research Papers:

Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients

Jun Ju, Jia Wang, Chao Ma, Yun Li, Zhenyan Zhao, Tao Gao, Qianwei Ni and Moyi Sun _

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Oncotarget. 2016; 7:51059-51068. https://doi.org/10.18632/oncotarget.10595

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Abstract

Jun Ju1,*, Jia Wang2,*, Chao Ma1,*, Yun Li1, Zhenyan Zhao1, Tao Gao1, Qianwei Ni1 and Moyi Sun1

1 State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xincheng, Xi'an, Shaanxi, China

2 State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomology, Fourth Military Medical University, Xincheng, Xi'an, Shaanxi, China

* These authors have contributed equally to this work

Correspondence to:

Moyi Sun, email:

Keywords: head and neck squamous cell carcinoma, nomogram, overall survival, cancer-specific survival, prognosis

Received: April 16, 2016 Accepted: June 13, 2016 Published: July 13, 2016

Abstract

This study aimed to develop nomograms to predict long-term overall survival and cancer-specific survival in patients with head and neck squamous cell carcinoma (HNSCC). We conducted prognostic analyses and developed nomograms predicting survival outcome using HNSCC patient data collected from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. An external dataset of 219 patients was used to validate the nomograms. Of 36,179 HNSCC patients, 9,627 (26.6%) died from HNSCC and 4,229 (11.7%) died from other causes. Median follow-up was 28 months (1-107 months). Nomograms predicting overall survival (OS) and cancer-specific survival (CSS) were developed according to 10 clinicopathologic factors (age, race, sex, tumor site, tumor grade, surgery, radiotherapy and TNM stage), with concordance indexes (C-indexes) of 0.719 and 0.741, respectively. External validation C-indexes were 0.709 and 0.706 for OS and CSS, respectively. Our results suggest that we successfully developed nomograms predicting five- and eight-year HNSCC patient OS and CSS with high accuracy. These nomograms could help clinicians tailor surgical, adjuvant therapeutic and follow-up strategies to more effectively treat HNSCC patients.


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