Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway
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Liang Wang1,*, Zhenxian Zhao2,*, Weidong Feng1,*, Zhijun Ye1, Weigang Dai1, Changhua Zhang1, Jianjun Peng1, Kaiming Wu1
1Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
2Department of Biliary Pancreatic Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
*These authors contributed equally to this work
Kaiming Wu, email: [email protected]
Keywords: long noncoding RNA,TUG1, CRC, EMT
Received: March 04, 2016 Accepted: May 19, 2016 Published: July 13, 2016
Colorectal cancer (CRC) is the third most common malignancy in developed countries, and its incidence rate has been continuously increasing in developing countries over the past few decades. Taurine-upregulated gene 1 (TUG1) plays an important role in signal transduction, regulation of cell morphology, migration, proliferation and apoptosis. The aim of the present study was to evaluate the role of TUG1 in CRC, and whether knockdown of TUG1 expression could affect cell proliferation, migration and invasion of CRC cell lines. Here, we reported that TUG1 was upregulated in CRC. Further experiments revealed that TUG1 knockdown significantly inhibited cell proliferation, migration and invasion of CRC in vitro. Above all, knockdown of TUG1 may represent a rational therapeutic strategy for CRC patients in future.
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