LncRNAs in pancreatic cancer

Xiaoyi Huang, Xiaosong Zhi, Yisha Gao, Na Ta, Hui Jiang and Jianming Zheng _

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Oncotarget. 2016; 7:57379-57390. https://doi.org/10.18632/oncotarget.10545

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Xiaoyi Huang1,*, Xiaosong Zhi2,*, Yisha Gao1, Na Ta1, Hui Jiang1 and Jianming Zheng1

1 Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China

2 Department of Cell Biology, Second Military Medical University, Shanghai, China

* These authors have contributed equally to this work

Correspondence to:

Jianming Zheng, email:

Hui Jiang, email:

Keywords: pancreatic cancer; lncRNA; pathogen; mechanism; clinical

Received: March 23, 2016 Accepted: June 17, 2016 Published: July 12, 2016


Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The underlying mechanism of PC is not completely understood at present. Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation. Notably, expressions of some lncRNAs undergo significant changes in the initiation and progression of cancers. In addition, lncRNAs are reported to be involved in various steps of PC development and have a potential value in the diagnosis, treatment and prognostic prediction of PC. In this review, we highlight recent evidence related to the molecular mechanism of lncRNAs in growth, survival, invasion, metastasis, angiogenesis and apoptosis of PC cells, and discuss the potential clinical application of lncRNAs to the diagnosis, treatment and prognostic prediction of PC.

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