Research Papers:

Clinicopathological and prognostic significance of platelet to lymphocyte ratio in patients with gastric cancer

Xiaobin Gu, Xian-Shu Gao _, Ming Cui, Mu Xie, Chuan Peng, Yun Bai, Wei Guo, Linjun Han, Xiaodong Gu and Wei Xiong

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Oncotarget. 2016; 7:49878-49887. https://doi.org/10.18632/oncotarget.10490

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Xiaobin Gu1, Xian-Shu Gao1, Ming Cui1, Mu Xie1, Chuan Peng1, Yun Bai1, Wei Guo2, Linjun Han2, Xiaodong Gu3, Wei Xiong4

1Department of Radiation Oncology, Peking University First Hospital, Peking University, Beijing, China

2Graduate School of Medicine, Hebei North University, Zhangjiakou, Hebei, China

3Department of Breast Cancer Radiotherapy, Tumor Hospital of Shanxi Provence, Taiyuan, China

4Department of Oncology, Tangshan People’s Hospital, Hebei, China

Correspondence to:

Xian-Shu Gao, email: [email protected]

Keywords: PLR, gastric cancer, biomarker, prognosis, meta-analysis

Received: March 29, 2016     Accepted: June 30, 2016     Published: July 08, 2016


The present study was aim to investigate the prognostic role of platelet to lymphocyte ratio (PLR) for patients with gastric cancer (GC) using meta-analysis. A total of 13 studies (14 cohorts) with 6,280 subjects were included. By pooling hazard ratios (HRs) and 95% confidence intervals (CIs) and odds ratios (ORs) and 95% CIs from each study, we found that elevated PLR was significantly associated with poorer overall survival (OS) (HR: 1.3, 95% CI: 1.1–1.52, p = 0.001; Ι² = 68.5%, Ph < 0.001) but not with poor disease-free survival (DFS) (HR: 1.6, 95% CI: 0.88–2.9, p = 0.122; I2 = 87.8%, Ph < 0.001). Subgroup analysis showed that a high PLR significantly predicted poor OS in Caucasian populations, patients receiving chemotherapy and patients at advanced stage. In addition, the cut-off value of PLR > 160 showed adequately prognostic value. Furthermore, elevated PLR was associated with lymph node metastasis and CEA levels in GC. Our meta-analysis showed that elevated PLR could be a significant prognostic biomarker for poor OS in patients with GC.

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