Oncotarget

Research Papers:

Long non-coding RNA-H19 antagonism protects against renal fibrosis

Hong Xie, Jing-Dong Xue, Feng Chao, Yan-Feng Jin and Qiang Fu _

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Oncotarget. 2016; 7:51473-51481. https://doi.org/10.18632/oncotarget.10444

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Abstract

Hong Xie1, Jing-Dong Xue1, Feng Chao1, Yan-Feng Jin1, Qiang Fu1

1Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

Correspondence to:

Qiang Fu, email: [email protected]

Keywords: long non-coding RNA, renal fibrosis, microRNA, unilateral ureteral obstruction

Received: April 07, 2016     Accepted: June 06, 2016     Published: July 06, 2016

ABSTRACT

Although long non-coding RNAs (lncRNAs) are important players in the initiation and progression of many pathological processes, the role of lncRNAs in renal fibrosis still remains unclear. We showed that lncRNA-H19 expression was significantly up-regulated in TGF-β2-induced HK-2 cell fibrosis and unilateral ureteral obstruction (UUO)-induced renal fibrosis in vivo. H19 knockdown significantly attenuated renal fibrosis in vitro and in vivo. LncRNA-H19, miR-17, and fibronectin constituted to a regulatory network involved in renal fibrosis. We also detected up-regulated H19 expression and down-regulated miR-17 expression in the early and advanced animal models of renal fibrosis. This study indicates that H19 up-regulation contributes to renal fibrosis. H19 inhibition might represent a novel anti-fibrotic treatment in renal diseases.


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