Long non-coding RNA-H19 antagonism protects against renal fibrosis
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Hong Xie1, Jing-Dong Xue1, Feng Chao1, Yan-Feng Jin1, Qiang Fu1
1Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Qiang Fu, email: [email protected]
Keywords: long non-coding RNA, renal fibrosis, microRNA, unilateral ureteral obstruction
Received: April 07, 2016 Accepted: June 06, 2016 Published: July 06, 2016
Although long non-coding RNAs (lncRNAs) are important players in the initiation and progression of many pathological processes, the role of lncRNAs in renal fibrosis still remains unclear. We showed that lncRNA-H19 expression was significantly up-regulated in TGF-β2-induced HK-2 cell fibrosis and unilateral ureteral obstruction (UUO)-induced renal fibrosis in vivo. H19 knockdown significantly attenuated renal fibrosis in vitro and in vivo. LncRNA-H19, miR-17, and fibronectin constituted to a regulatory network involved in renal fibrosis. We also detected up-regulated H19 expression and down-regulated miR-17 expression in the early and advanced animal models of renal fibrosis. This study indicates that H19 up-regulation contributes to renal fibrosis. H19 inhibition might represent a novel anti-fibrotic treatment in renal diseases.
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