Rapamycin in aging and disease: maximizing efficacy while minimizing side effects

Simon C. Johnson; Matt Kaeberlein

doi:10.18632/oncotarget.10381

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Perspectives:

Rapamycin in aging and disease: maximizing efficacy while minimizing side effects

Simon C. Johnson and Matt Kaeberlein _

PDF | HTML | How to cite

Oncotarget. 2016; 7:44876-44878. https://doi.org/10.18632/oncotarget.10381

Metrics: PDF 3279 views | HTML 4328 views | ?

Abstract

Simon C. Johnson1 and Matt Kaeberlein2

1 Department of Genetics, Albert Einstein Medical College, New York, NY, USA

2 Department of Pathology, University of Washington, Seattle, WA, USA

Correspondence to:

Matt Kaeberlein, email:

Keywords: mTOR, target of rapamycin, healthspan, mitochondria, mitochondria disease

Received: April 22, 2016 Accepted: June 16, 2016 Published: July 01, 2016

Abstract

Experimental geroscience has identified rapamycin as a top candidate for promoting healthy aging and longevity in mammals. As multiple independent studies have successfully reproduced the lifespan and healthspan promoting effects of rapamycin, the focus has shifted to possible translational use. While a promising compound, clinical use of rapamycin is limited by concerns of side effects associated with the drug. Studies aimed at defining optimal dosage regimen, delivery route, and formulation will allow for benefits to be maximized while reducing side effects.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 10381

Publication Alerts

Research Perspectives:

Rapamycin in aging and disease: maximizing efficacy while minimizing side effects

Abstract