Research Papers:

Thyroid functional parameters and correlative autoantibodies as prognostic factors for differentiated thyroid cancers

Chao Li, Wenbin Yu, Jinchuan Fan, Guojun Li, Xiaofeng Tao, Yun Feng _ and Ronghao Sun

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Oncotarget. 2016; 7:49930-49938. https://doi.org/10.18632/oncotarget.10236

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Chao Li1,*, Wenbin Yu2,*, Jinchuan Fan1, Guojun Li3,4, Xiaofeng Tao5, Yun Feng6, Ronghao Sun1

1Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China

2Department of Head and Neck surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China

3Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

4Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

5Department of Radiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

6Department of Otorhinolaryngology Head & Neck Surgery, China-Japan Friendship Hospital, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Yun Feng, email: [email protected]

Ronghao Sun, email: [email protected]

Keywords: differentiated thyroid carcinoma, thyroid functional parameters, thyroid correlative autoantibodies, prognostic factors

Received: May 24, 2016     Accepted: June 13, 2016     Published: June 23, 2016


To evaluate the effect of preoperative thyroid functional parameters and thyroid autoantibodies on aggressive clinicopathologic features and lymph node metastasis (LNM) of differentiated thyroid cancer patients. Four hundred twenty consecutive patients with initial surgery were enrolled from July 2010 to July 2015. The associations between aggressive clinicopathologic and LNM factors and thyroid functional & autoantibodies parameters were analyzed. Higher levels of TSH, TGAb or TMAb were found in patients with tumor size≥1 cm (all P<0.05), especially when TSH≥2.5 ulU/ml (P=0.03) and TGAb≥1 (P=0.01). Higher levels of TSH and TGAb and lower levels of T3 and T4 were found in patients with capsular invasion (all P<0.05), particularly when TSH≥2.5ulU/ml (P=0.03) and TGAb≥1 (P=0.005). The patients with multifocality had higher TAbs level (TAbs>1). Higher level of TSH was also found in patients with central LNM (P=0.001) and lateral LNM (P=0.002), especially with TSH≥2.5ulU/ml (P=0.003 and P=0.03). TGAb level was also found higher in patients with central LNM (P=0.02) and lateral LNM (P=0.01), especially with TGAb≥1 (P<0.05 and P=0.01). Higher level of TMAb was found in patients with lateral LNM (P<0.05). Moreover, multivariable analysis revealed that only TGAb was an independently predictive factor for primary tumor size≥1cm (P=0.01); and TSH level (P=0.01) and TGAb≥1 (P<0.05) were associated independently with central LNM. Thus, TSH level and TGAb≥1 were significantly independent predictors for central LNM, and might help make the decision of central neck dissection.

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