Evaluating prognosis by CK7 differentiating renal cell carcinomas from oncocytomas can be used as a promising tool for optimizing diagnosis strategies
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Fuling Ma1,*, Liang Dai1,*, Zhun Wang1,*, Liqun Zhou2, Yuanjie Niu1, Ning Jiang1
1Department of Urology, 2nd Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211,China
2Department of Urology, Peking University First Hospital, The Institute of Urology, Peking University, Beijing 100034, China
*These authors have contributed equally to this work
Liqun Zhou, email: firstname.lastname@example.org
Yuanjie Niu, email: email@example.com
Ning Jiang, email: firstname.lastname@example.org
Keywords: CK7, renal carcinomas, meta-analysis
Received: October 16, 2015 Accepted: May 13, 2016 Published: June 22, 2016
Renal Oncocytomas and renal cell carcinomas (RCCs) share a common phenotype. This makes it very difficult to differentiate between the two tumors. Here, this study was to confirmed and expanded the findings that CK7 as a promising tool differentiate RCC from Oncocytomas across various geographic regions. A systematic search of databases was carried out and other relevant articles were also identified. Then the meta-analyses were conducted for 1,711 participants according to the standard guidelines. A total of 21 studies were included on the basis of inclusion criteria. CK7 by IHC was significantly associated with increased diagnosis of RCC (OR=10.64; 95% CI, 7.44-15.23; P=0.0001). Subgroup-analysis showed that findings didn’t substantially change when only Caucasians or Asians (OR=10.58; 95% CI, 6.97-16.07; P<0.01 or OR=10.83; 95% CI, 5.39-21.74; P=0.004) were considered. There was also no significant publication bias observed. Our findings provide further evidences that the expression of CK7 contribute to differentiate RCC from Oncocytomas. CK7 protein overexpression was found in RCC, low expression in any of Oncocytomas. CK7 is potentially an important renal tumor marker.
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