Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer
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Chunjing Jin1,*, Wei Shi2,*, Feng Wang3,*, Xianjuan Shen2, Jing Qi2, Hui Cong3, Jie Yuan1, Linying Shi1, Bingying Zhu1, Xi Luo1, Yan Zhang1, Shaoqing Ju2,3
1Medical School of Medicine, Nantong University, Nantong 226000, Jiangsu Province, China
2Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong 226000, Jiangsu Province, China
3Laboratory Medicine Center, Afﬁliated Hospital of Nantong University, Nantong 226000, Jiangsu Province, China
*These authors have contributed equally to the work
Shaoqing Ju, email: [email protected]
Keywords: gastric cancer, long non-coding RNA, biomarker, HULC
Received: January 25, 2016 Accepted: May 02, 2016 Published: June 16, 2016
Long non-coding RNAs (lncRNAs) have recently emerged as vital players in tumor biology with potential value in cancer diagnosis, prognosis, and therapeutics. The lncRNA HULC (highly up-regulated in liver cancer) is increased in many malignancies, yet its serum expression profile and clinical value in gastric cancer (GC) patients remain unclear. Quantitative real-time polymerase chain reaction (RT-qPCR) for large-scale analysis of the serum expression of HULC in GC patients reliably detected circulating HULC and revealed that it is upregulated in GC patients. A high serum HULC level correlated with tumor size, lymph node metastasis, distant metastasis, tumor-node-metastasis stage, and H. pylori infection. The area under the ROC curve for HULC was up to 0.888, which was higher than that for CEA (0.694) and CA72-4 (0.514). Follow-up detection and Kaplan-Meier curve analysis revealed HULC is a good predictor of GC prognosis. Our present study indicates that circulating HULC may represent a novel serum tumor marker for early diagnosis and monitoring progression and prognosis of GC.
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