Research Papers: Pathology:

Clinicopathological and immunohistochemical characterization of papillary proliferation of the endometrium: A single institutional experience

Cheol Keun Park, Gun Yoon, Yoon Ah Cho and Hyun-Soo Kim _

PDF  |  HTML  |  How to cite

Oncotarget. 2016; 7:39197-39206. https://doi.org/10.18632/oncotarget.10049

Metrics: PDF 3083 views  |   HTML 3959 views  |   ?  


Cheol Keun Park1, Gun Yoon2, Yoon Ah Cho1 and Hyun-Soo Kim1

1 Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

2 Department of Obstetrics and Gynecology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan-si, Gyeongsangnam-do, Republic of Korea

Correspondence to:

Hyun-Soo Kim, email:

Keywords: papillary proliferation, endometrium, atypical hyperplasia/endometrioid intraepithelial neoplasia, endometrioid carcinoma, immunohistochemistry, Pathology Section

Received: April 25, 2016Accepted: June 04, 2016Published: June 14, 2016


Papillary proliferation of the endometrium is an unusual lesion that is composed of papillae with fibrovascular stromal cores covered with benign-appearing glandular epithelium. We studied the clinicopathological and immunohistochemical features of four cases of endometrial papillary proliferations. All patients were postmenopausal. Two lesions were incidental findings in hysterectomy specimens, and two lesions were detected in endometrial curettage specimens. Based on the degree of architectural complexity and extent of proliferation, we classified papillary proliferations histopathologically into “simple” or “complex” growth patterns. Three cases were classified as simple papillary proliferation, and one case was classified as complex papillary proliferation. Simple papillary proliferations were characterized by slender papillae with delicate stromal cores. In contrast, complex papillary proliferations had intracystic papillary projections and cellular clusters with frequent branching and occasional cytological atypia. All cases showed coexistent metaplastic epithelial changes, including mucinous metaplasia, eosinophilic cell change, and ciliated cell metaplasia. One patient with simple papillary proliferations had coexistent well-differentiated endometrioid carcinoma. One patient had subsequent hyperplasia without atypia, and another patient had subsequent atypical hyperplasia/endometrioid intraepithelial neoplasia; both patients underwent total hysterectomy within four months. Our observations are consistent with previous data demonstrating that endometrial papillary proliferations coexist with or develop into atypical hyperplasia/endometrioid intraepithelial neoplasia or endometrioid carcinoma. It is very important for pathologists to discriminate papillary proliferations from neoplastic lesions (including atypical hyperplasia/endometrioid intraepithelial neoplasia and well-differentiated endometrioid carcinoma) and benign mimickers (including papillary syncytial metaplasia).

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 10049