Oncotarget

Research Papers:

A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer

Ben Liu, Xining Zhang, Fengju Song, Qun Liu, Hongji Dai, Hong Zheng, Ping Cui, Lina Zhang, Wei Zhang and Kexin Chen _

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Oncotarget. 2016; 7:34277-34287. https://doi.org/10.18632/oncotarget.9099

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Abstract

Ben Liu1,*, Xining Zhang1,*, Fengju Song1, Qun Liu1,2, Hongji Dai1, Hong Zheng1, Ping Cui1, Lina Zhang1, Wei Zhang3,4, Kexin Chen1

1Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China

2Departments of Neurosurgery, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China

3Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

4Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA

*These authors contributed equally to this work

Correspondence to:

Kexin Chen, email: chenkexin@tjmuch.com

Wei Zhang, email: wzhang@mdanderson.org, wezhang@wakehealth.edu

Keywords: SET8, single nucleotide polymorphisms (SNP), rs16917496, prognosis, breast cancer

Received: November 30, 2015     Accepted: April 10, 2016     Published: April 29, 2016

ABSTRACT

A single-nucleotide polymorphism (SNP) locus rs16917496 (T > C) within the 3′-untranslated region (3′-UTR) of SET8 was associated with susceptibility in several malignancies including breast cancer. To further elucidate the prognostic relevance of this SNP in breast cancer, we conducted a clinical study as well as SET8 expression analysis in a cohort of 1,190 breast cancer patients. We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival. SET8 expression was significantly higher in breast tumor tissue than in paired adjacent normal tissue. In addition, survival analysis in 315 patients showed SNP rs16917496 was an independent prognostic factor of breast cancer outcome with TT genotype associated with poor survival compared with CC/CT genotypes. Thus, this SNP may serve as a genetic prognostic factor and a treatment target for breast cancer. Future studies are warranted.


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