Oncotarget

Research Papers:

Analysis of overall survival in a large multiethnic cohort reveals absolute neutrophil count of 1,100 as a novel prognostic cutoff in African Americans

Ioannis Mantzaris _, Yiting Yu, Pavlos Msaouel, Anthony P. Lam, Murali Janakiram, Ellen W. Friedman, Ulrich Steidl, Amit K. Verma

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Oncotarget. 2016; 7:67948-67955. https://doi.org/10.18632/oncotarget.8996

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Abstract

Ioannis Mantzaris1, Yiting Yu1, Pavlos Msaouel2, Anthony P. Lam3, Murali Janakiram1, Ellen W. Friedman1, Ulrich Steidl1, Amit K. Verma1

1Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA

2Department of Medicine, Albert Einstein College of Medicine, Jacobi Medical Center, Bronx, New York, USA

3Department of Oncology, Stanford University, Stanford, CA, USA

Correspondence to:

Ioannis Mantzaris, email: i.mantzar@montefiore.org

Amit K. Verma, email: amit.verma@einstein.yu.edu

Keywords: neutropenia, survival, African American, ethnicity, race

Received: February 14, 2016     Accepted: March 31, 2016     Published: April 26, 2016

ABSTRACT

Although absolute neutrophil counts (ANC) below 1.5x103/uL are used to define neutropenia as a marker of increased susceptibility to infections, their relationship with survival has not been examined. Since low counts trigger extensive investigations, determining prognostic cutoffs especially for different ethnicities and races is critical.

A multiethnic cohort of 27,760 subjects, 65 years old and above, was utilized to evaluate the association of neutropenia with overall survival in different ethnicities and races.

The mean ANC was 4.6±1.51x103/uL in non-Hispanic whites, 3.6±1.57x103/uL in non-Hispanic blacks and 4.3±1.54x103/uL in Hispanics (p<0.001). An ANC below 1.5x103/uL was associated with significantly shorter overall survival among whites (HR 1.74; 95% CI 1.18 - 2.58; p<0.001), but not in blacks (HR 0.89; 95% CI 0.86 - 1.17; p=0.40) or Hispanics (HR 1.04; 95% CI 0.76 - 1.46; p=0.82), after adjustment for age, sex, comorbidities, anemia and thrombocytopenia. Using Cox regression multivariable models, an ANC below 1.1x103/uL in blacks was found to be associated with increased mortality (HR 1.86; 95%CI 1.21 - 2.87; p<0.01). We found no association between neutropenia and mortality at any ANC cutoff in elderly Hispanics. In conclusion, neutropenia was found to be an independent prognostic variable in the elderly, when determined in race-specific manner. Most importantly, a cutoff of 1.1x103 neutrophils/uL may be a more prognostically relevant marker in elderly blacks and could serve as a novel threshold for further evaluation and intervention in this population.


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PII: 8996