Oncotarget

Research Papers:

The microRNA-124-iGluR2/3 pathway regulates glucagon release from alpha cells

Haiyang Zhang, Rui Liu, Ting Deng, Xia Wang, Hongmei Lang, Yanjun Qu, Jingjing Duan, Dingzhi Huang, Guoguang Ying and Yi Ba _

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Oncotarget. 2016; 7:24734-24743. https://doi.org/10.18632/oncotarget.8270

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Abstract

Haiyang Zhang1, Rui Liu1, Ting Deng1, Xia Wang1, Hongmei Lang2, Yanjun Qu1, Jingjing Duan1, Dingzhi Huang1, Guoguang Ying1, Yi Ba1

1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China

2Department of Endocrinology, Chengdu Military General Hospital, Chengdu, Sichuan 610083, China

Correspondence to:

Yi Ba, e-mail: bayi@tjmuch.com

Guoguang Ying, e-mail: yingguoguang163@163.com

Keywords: glucagon, α cell, iGluR2/3, miR-124, metabolism

Received: January 20, 2016     Accepted: March 07, 2016     Published: March 22, 2016

ABSTRACT

Glucagon, secreted from islet alpha cells, plays an important role in regulating glucose homeostasis; however, the molecular mechanism underlying this process is not fully understood. Previous studies have demonstrated that miRNAs are involved in the function of alpha cells. Glutamate promotes glucagon secretion by mediating the opening of Ca2+ channels. In this present, iGluR2 and iGluR3 levels were significantly increased in fasting-treated mouse islets. Additional studies showed that miR-124-3p simultaneously regulates the expression of iGluR2 and iGluR3 through the direct targeting of mRNA 3’UTR of these two genes. The miR-124-iGluRs pathway also contributed to the high level of glucagon secretion through long-term high glucose levels. Thus, a novel pathway comprising miRNA, glutamate and iGluRs has been demonstrated to regulate the biological process of glucagon release.


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