Oncotarget

Research Papers:

The demographic features, clinicopathologic characteristics, treatment outcome and disease-specific prognostic factors of solitary fibrous tumor: a population-based analysis

Alimujiang Wushou, Yi-Zhou Jiang, Yi-Rong Liu, Zhi-Ming Shao _

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Oncotarget. 2015; 6:41875-41883. https://doi.org/10.18632/oncotarget.6174

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Abstract

Alimujiang Wushou1,2, Yi-Zhou Jiang1,2, Yi-Rong Liu1,2 and Zhi-Ming Shao1,2

1 Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China

2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

Correspondence to:

Zhi-Ming Shao, email:

Keywords: Solitary fibrous tumor and SEER analysis

Received: August 09, 2015 Accepted: October 06, 2015 Published: October 19, 2015

Abstract

Background: Solitary fibrous tumor’s (SFT) demographic features, clinicopathologic characteristics, treatment outcome and disease-specific prognostic factors were unexplored comprehensively.

Methods: SEER program was used to identify patients diagnosed with SFT from 1973 to 2012. Overall collected data were analyzed by using the SPSS 18.0.

Results: In total, 804 cases were found including 613 cases with SFT-specific mortality and 801 patients were analyzed for overall survival (OS). The 3-year disease specific survival (DSS), 5-year DSS and 10-year DSS were 73.3%, 65.7% and 53.3%. The 3-year OS, 5-year OS and 10-year OS were 71.9%, 63.3% and 47.3%. In the multivariate survival analysis, the age > 51 years (hazard ratio [HR] = 1.851 for DSS, P = 0.024 and HR = 1.652 for OS, P = 0.033; Reference [Ref] ≤ 51 years for DSS and ≤ 53 years for OS), SEER stage metastasized tumor (HR = 4.269 for DSS, P = 0.000 and HR = 2.905 for OS, P = 0.028, Ref - localized + regional tumor), pathologic grade III + IV (HR = 2.734 for DSS, P = 0.001 and HR = 2.585 for OS, P = 0.000, Ref - grade I + II) were adversely associated with DSS and OS. In addition, surgery was favorably associated with DSS (HR = 0.217, P = 0.045, Ref - surgery + radiotherapy).

Conclusions: The surgery was an independent prognostic factor for DSS. The patient’s age, SEER stage and pathologic grade were SFT-specific independent prognostic indicators for DSS and OS.


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