Oncotarget

Research Papers: Pathology:

Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma

Ting-Ting Yan, Xue-Liang Fu, Jiao Li, Ying-Nan Bian, De-Jun Liu, Rong Hua, Lin-Lin Ren, Cheng-Tao Li, Yong-Wei Sun, Hao-Yan Chen, Jing-Yuan Fang and Jie Hong _

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Oncotarget. 2015; 6:37028-37042. https://doi.org/10.18632/oncotarget.5939

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Abstract

Ting-Ting Yan1,*, Xue-Liang Fu2,*, Jiao Li2,*, Ying-Nan Bian3,*, De-Jun Liu2, Rong Hua2, Lin-Lin Ren1, Cheng-Tao Li3,Yong-Wei Sun2, Hao-Yan Chen1, Jing-Yuan Fang1 and Jie Hong1

1 Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Institution of Digestive Disease, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Genes, Shanghai Jiao-Tong University School of Medicine, Shanghai, China

2 Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China

3 Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, Shanghai, China

* These authors have contributed equally to this work

Correspondence to:

Jie Hong, email:

Jing-Yuan Fang, email:

Yong-Wei Sun, email:

Hao-Yan Chen, email:

Keywords: pancreatic cancer, RPL15, metastasis, biomarker, PDAC, Pathology Section

Received: April 20, 2015 Accepted: September 17, 2015 Published: October 15, 2015

Abstract

Early diagnosis and treatment in pancreatic ductal adenocarcinoma (PDAC) is still a challenge worldwide. The poor survival of PDAC patients mainly due to early metastasis when first diagnosed and lack of prognostic biomarker. Ribosomal protein L15 (RPL15), an RNA-binding protein, is a component of ribosomal 60S subunit. It was reported that RPL15 is dysregulated in various type of cancers. However, little is known about the role of RPL15 in PDAC carcinogenesis and progression. Herein, we clarified RPL15 expression status may serve as an independent prognostic biomarker in three independent PDAC patient cohorts. We found that RPL15 was dramatically decreased in PDAC tissues and cell lines. The high expression of RPL15 was inversely correlated with TNM stage, histological differentiation, T classification and vascular invasion. Low expression of RPL15 was significantly associated with poor overall survival of PDAC patients. Furthermore, we demonstrated that the reduction of RPL15 may promote invasion ability of pancreatic cell by inducing EMT process. In conclusion, decreased RPL15 expression is associated with invasiveness of PDAC cells, and RPL15 expression status may serve as a reliable prognostic biomarker in PDAC patients.


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