Oncotarget

Clinical Research Papers:

Synchronous occurrence of gastrointestinal stromal tumors and other digestive tract malignancies in the elderly

Chaoyong Shen _, Haining Chen, Yuan Yin, Jiaju Chen, Luyin Han, Bo Zhang, Zhixin Chen and Jiaping Chen

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Oncotarget. 2015; 6:8397-8406. https://doi.org/10.18632/oncotarget.3108

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Abstract

Chaoyong Shen1,*, Haining Chen1,*, Yuan Yin1, Jiaju Chen1, Luyin Han2, Bo Zhang1, Zhixin Chen1, Jiaping Chen1

1Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

2Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China

*These authors have contributed equally to this work

Correspondence to:

Bo Zhang, e-mail: hxwcwk@126.com

Keywords: gastrointestinal stromal tumors, synchronous neoplasm, digestive tract malignancies, elderly

Received: December 07, 2014     Accepted: January 08, 2015     Published: February 27, 2015

ABSTRACT

Background/Aims

Elderly patients with gastrointestinal stromal tumors (GISTs) synchronous with other digestive tract malignancies have been rarely reported. In this study, clinicopathological characteristics were evaluated among elderly patients with GISTs with or without coexisting digestive tract malignancies.

Methods

A total of 161 patients (≥65 years) were retrospectively reviewed at the West China Hospital, Sichuan University from January 2009 to June 2014.

Results

Sixty-one patients were diagnosed with synchronous digestive tract malignancies (synchronous group), whereas 100 patients were diagnosed with no synchronous condition (no-synchronous group). The synchronous group exhibited a higher percentage of males (70.49% vs. 53.00%, P = 0.028) and poorer Eastern Cooperative Oncology Group performance status than the no-synchronous group (P = 0.029). The three-year overall survival (OS) rate was significantly lower among patients with synchronous digestive tract malignancies than that among patients without synchronous condition (64.5% vs. 84.0%, P = 0.003). Multivariate analysis showed that the presence of synchronous digestive tract malignancies (P = 0.002), co-morbidity (P = 0.004), and mitotic count ≥10 mitoses/50 high power fields (P = 0.012) were associated with poor OS.

Conclusions

A synchronous condition with other digestive tract malignancies is common in elderly patients with GISTs. OS primarily depends on synchronous digestive tract malignancies, mitotic count, and co-morbidity.


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