Strong Inhibition of Xenografted Tumor Growth by Low-Level Doses of [32P]ATP
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1 Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287
2 Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21287
Keywords: xenografts, inhibition, nude mice
Received: June 3, 2011; Accepted: June 3, 2011; Published: June 5, 2011;
Stephen J. Meltzer, e-mail:
John M. Abraham, e-mail:
The ability of a potential human anti-cancer therapeutic agent to inhibit the growth of xenografted tumors in nude mice has been an established and accepted testing method for several decades. The current report shows that a single, low-level intravenous dose of [32P]ATP significantly inhibits the growth of established xenografted tumors in nude mice. This inhibitory effect becomes appreciable very rapidly, within only five days post-injection and the low dose demonstrates little or no toxicity in the mice. Surprisingly, a narrow dose window of optimum effectiveness is seen, whereby either decreasing or increasing the [32P]ATP dose results in far less growth inhibition. Thus, the intravenous systemic injection of [32P]ATP may represent a simple, potent method to target and inhibit primary human tumors and malignant lesions.
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