Claudin3 is localized outside the tight junctions in human carcinomas

Michela Corsini; Antonella Ravaggi; Franco Odicino; Alessandro Davide Santin; Cosetta Ravelli; Marco Presta; Chiara Romani; Stefania Mitola

doi:10.18632/oncotarget.24858

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Research Papers:

Claudin3 is localized outside the tight junctions in human carcinomas

Michela Corsini, Antonella Ravaggi, Franco Odicino, Alessandro Davide Santin, Cosetta Ravelli, Marco Presta, Chiara Romani _ and Stefania Mitola

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Oncotarget. 2018; 9:18446-18453. https://doi.org/10.18632/oncotarget.24858

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Abstract

Michela Corsini1, Antonella Ravaggi2, Franco Odicino2, Alessandro Davide Santin3, Cosetta Ravelli1,4, Marco Presta1, Chiara Romani2,* and Stefania Mitola1,4,*

1Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

2Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 'Angelo Nocivelli' Institute of Molecular Medicine, University of Brescia, Brescia, Italy

3Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

4Department of Molecular and Translational Medicine, Laboratory for Preventive e Personalized Medicine, University of Brescia, Brescia, Italy

*These authors have contributed equally to this work

Correspondence to:

Chiara Romani, email: [email protected]

Stefania Mitola, email: [email protected]

Keywords: claudin3; tight junction; ovarian cancer; uterine cancer

Received: October 05, 2017 Accepted: March 06, 2018 Published: April 06, 2018

ABSTRACT

Claudin3 is an integral component of the tight junction proteins in polarized epithelia. The expression of claudin3 was assessed in epithelial-derived tumors using Oncomine database. To determine the gene alteration during carcinogenesis, copy number alterations and mutations of claudin3 were evaluated using cBioPortal database. Claudin3 is overexpressed in several tumors including gynecological, bladder, breast and prostate carcinomas. 38% of the 163 evaluated studies show mutations and/or amplification of claudin3. 3D reconstruction of tissue samples following immunofluorescence analysis clearly demonstrated that, unlike in healthy tissues, claudin3 is mislocalized and unengaged in the formation of tight junction in tumor samples. These data strongly support the evaluation of unengaged claudin3 as a target for the development of novel diagnostic probes, optical approaches for real time detection of tumoral tissues during surgery, and target therapeutic drugs.

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Research Papers:

Claudin3 is localized outside the tight junctions in human carcinomas

Abstract