Metabolomics insights into collagen-induced arthritis in mice and its treatment with wenjinghuoluo prescription

Xin Wu; Yaodong You; Xiaocheng Chen; Qiyang Shou; Songqi Tang; Jida Zhang; Hao Cai; Baochang Cai; Dongxin Tang; Gang Cao

doi:10.18632/oncotarget.24241

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Research Papers:

Metabolomics insights into collagen-induced arthritis in mice and its treatment with wenjinghuoluo prescription

Xin Wu _, Yaodong You, Xiaocheng Chen, Qiyang Shou, Songqi Tang, Jida Zhang, Hao Cai, Baochang Cai, Dongxin Tang and Gang Cao

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Abstract

Xin Wu1,*, Yaodong You2,*, Xiaocheng Chen3,*, Qiyang Shou4, Songqi Tang5, Jida Zhang6, Hao Cai7, Baochang Cai7, Dongxin Tang8 and Gang Cao1

1Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou, China

2School of Clinical Medicine, Chengdu University of TCM, Chengdu, China

3The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

4Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou, China

5College of TCM, Hainan Medical University, Haikou, China

6College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China

7School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China

8Guiyang University of Chinese Medicine, Guiyang, China

*These authors contributed equally to this work

Correspondence to:

Gang Cao, email: [email protected]

Dongxin Tang, email: [email protected]

Keywords: UHPLC-Orbitrap-MS; metabolomics; collagen-induced arthritis; wenjinghuoluo prescription; herbal formula

Received: July 20, 2017 Accepted: December 06, 2017 Published: January 02, 2018

ABSTRACT

Wenjinghuoluo (WJHL) prescription, the typical rheumatoid arthritis (RA) treatment compound in traditional Chinese medicine, shows favorable efficacy. The precise mechanism of WJHL on RA therapy is yet to be elucidated. This study aimed to determine the metabolic biomarkers in the early onset of RA and evaluate the regulation effect of WJHL on metabolite levels. Multivariate statistical analysis identified 93 biomarkers by precise MS/MS. These biomarkers played an important role in the regulation of key metabolic pathways associated with collagen-induced arthritis (CIA). A total of 68 biomarkers were related with the treatment of CIA by WJHL therapy. In addition, pathway analysis results showed six and three significant related pathways according to corresponding differential metabolites before and after WJHL therapy. Finally, disease and function prediction of ingenuity pathway analysis indicated that lipid metabolism, small molecule biochemistry, and carbohydrate metabolism were associated functions of WJHL therapy on CIA. Furthermore, top analysis-ready molecules of up-regulated thiamine and down-regulated arachidomic acid maybe the most related metabolites of WJHL therapy on CIA. The present work indicated that a metabolomics platform provided a new insight into understanding the mechanisms of action of natural medicines, such as WJHL.

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Research Papers:

Metabolomics insights into collagen-induced arthritis in mice and its treatment with wenjinghuoluo prescription

Abstract