Oncotarget

Clinical Research Papers:

Coronary artery disease risk in young women with polycystic ovary syndrome

Dah-Ching Ding _, I-Ju Tsai, Jen-Hung Wang, Shinn-Zong Lin, Fung-Chang Sung

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Oncotarget. 2018; 9:8756-8764. https://doi.org/10.18632/oncotarget.23985

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Abstract

Dah-Ching Ding1,2, I-Ju Tsai3,4, Jen-Hung Wang5, Shinn-Zong Lin6 and Fung-Chang Sung3,7

1Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan

2Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan

3Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

4College of Medicine, China Medical University, Taichung, Taiwan

5Department of Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan

6Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan

7Department of Health Services Administration, China Medical University, Taichung, Taiwan

Correspondence to:

Dah-Ching Ding, email: dah1003@yahoo.com.tw

Fung-Chang Sung, email: fcsung1008@yahoo.com

Keywords: cardiovascular disease; coronary artery disease; diabetes mellitus; hypertension; polycystic ovary syndrome

Received: August 02, 2017     Accepted: November 16, 2017     Published: January 04, 2018

ABSTRACT

Women with polycystic ovary syndrome are characterized by obesity, menstruation irregularity, hirsutism and infertility, and prevalent with cardiometabolic comorbidities, but population-based studies on the risk of developing coronary artery disease are limited. From claims data of the Taiwan National Health Insurance, we identified 8048 women with polycystic ovary syndrome aged 15-49 years newly diagnosed in 1998-2013, and 32192 women without the syndrome and CAD as controls, frequency matched by age and diagnosis date. By the end of 2013, after a mean follow-up period of 5.9 years, the overall incidence of coronary artery disease was 63% higher in women with polycystic ovary syndrome than in controls (2.25 vs. 1.38 per 1000 person-years). The adjusted hazard ratio [aHR] of coronary artery disease was 1.44 (95% confidence interval (CI) = 1.14–1.81) for women with polycystic ovary syndrome, compared with controls. Hazards of coronary artery disease were significant during follow-up periods of 3-4 years (aHR = 1.52, 95% CI = 1.00–2.30) and of 5–9 years (aHR = 1.58, 95% CI = 1.07–2.32). The incidence of coronary artery disease increased further in those with cardiometabolic comorbidities. Among women with polycystic ovary syndrome, those with comorbid diabetes had an incidence of 35.2 per 1000 person-years, 20-fold greater than those without cardiometabolic comorbidities. In conclusion, women with polycystic ovary syndrome are at an elevated risk of coronary artery disease. Preventive interventions should be provided to them, particularly for those with the comorbidity of metabolism symptom.


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