Oncotarget

Clinical Research Papers:

Neoadjuvant nimotuzumab plus chemoradiotherapy compared to neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for locally advanced esophageal squamous cell carcinoma

Yongshun Chen _, Xiaoyuan Wu, Daxuan Hao, Xinyu Cheng, Lei Zhang, Yougai Zhang, Shaobo Ke, Wei Shi and Chunyu He

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Oncotarget. 2019; 10:4069-4078. https://doi.org/10.18632/oncotarget.23861

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Abstract

Yongshun Chen1,2, Xiaoyuan Wu2, Daxuan Hao2, Xinyu Cheng2, Lei Zhang3, Yougai Zhang2, Shaobo Ke1, Wei Shi1 and Chunyu He2

1Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan, China

2Department of Radiation Oncology, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou, China

3Department of Nephrology, People’s Hospital of Tibet Autonomous Region, Tibet Autonomous Region, Lhasa, China

Correspondence to:

Yongshun Chen, email: yongshun2007@163.com

Keywords: esophageal cancer; locally advanced disease; neoadjuvant therapy; EGFR-inhibitor; pathological complete response

Received: August 14, 2017     Accepted: October 29, 2017     Epub: January 03, 2018     Published: June 18, 2019

ABSTRACT

Neoadjuvant therapy improves long-term locoregional control and overall survival after surgical resection for esophageal cancer, and neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT) are commonly used in clinical practice. Nimotuzumab is a humanized monoclonal antibody against epidermal growth factor receptor (EGFR), the efficacy of nimotuzumab added to nCRT for esophageal cancer is uncertain. We conducted this retrospective study in which combining neoadjuvant treatment of nimotuzumab with chemoradiotherapy (Nimo-nCRT) is compared with nCRT and nCT for patients with potentially resectable locally advanced esophageal squamous cell carcinoma. One hundred ninety-five patients received neoadjuvant therapy and 172 (88.2%) underwent esophagectomy. Surgical resection was performed in 94.4% after Nimo-nCRT, versus 92.5% after nCRT and 83.5% after nCT (P = 0.026). The R0 resection rate was 100% after Nimo-nCRT, 95.9% after nCRT and 92.6% after nCT (P = 0.030). Pathological complete response (pCR) was achieved in 41.2% after Nimo-nCRT, versus 32.4% after nCRT and 14.8% after nCT (P = 0.0001). Lymph-node metastases were observed in 29.4% in the Nimo-nCRT group, versus 21.6% in the nCRT group and 35.8% in the nCT group (P = 0.093). More patients in the Nimo-nCRT and nCRT group developed grade 3 esophagitis compared to those in the nCT group, P = 0.008. There was no difference in surgical complications between the treatment groups. nCRT results in improved R0 resection, higher pCR rate, and a lower frequency of lymph node metastases compared to nCT, adding nimotuzumab to nCRT is safe and appears to facilitate complete resection and increase the pCR rate.


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