Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma

Bei Li; Zhen You; Xian-Ze Xiong; Yong Zhou; Si-Jia Wu; Rong-Xing Zhou; Jiong Lu; Nan-Sheng Cheng

doi:10.18632/oncotarget.22694

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Research Papers:

Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma

Bei Li, Zhen You, Xian-Ze Xiong, Yong Zhou, Si-Jia Wu, Rong-Xing Zhou, Jiong Lu and Nan-Sheng Cheng _

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Oncotarget. 2017; 8:109468-109477. https://doi.org/10.18632/oncotarget.22694

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Abstract

Bei Li1,*, Zhen You1,*, Xian-Ze Xiong1, Yong Zhou1, Si-Jia Wu1, Rong-Xing Zhou1, Jiong Lu1 and Nan-Sheng Cheng1

1Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China

*These authors have contributed equally to this work

Correspondence to:

Nan-Sheng Cheng, email: [email protected]

Keywords: hilar cholangiocarcinoma; red blood cell distribution width; systemic inflammatory response; prognosis

Received: August 09, 2017 Accepted: October 05, 2017 Published: November 25, 2017

ABSTRACT

Background: Although the red blood cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, the prognostic value of RDW in hilar cholangiocarcinoma (HC) has not been studied.

Methods: A retrospective analysis of 292 consecutively recruited HC patients undergoing radical resection was conducted. The optimal cutoff value of RDW was determined by the receiver operating characteristic curve (ROC). Survival analysis by the Kaplan-Meier method, the difference between the clinico-pathologic variables and survival were evaluated by log-rank analysis. Multivariate analysis identified independent prognostic risk factors of overall survival (OS).

Results: ROC analysis suggested that the optimal cutoff value for the RDW was 14.95. Linear correlation analysis revealed that RDW is associated with white blood cell count (P = 0.007), neutrophil-to-lymphocyte ratio (P = 0.02), and hemoglobin (P < 0.001), albumin (P < 0.001). In a multivariate analysis, the RDW was an independent prognostic factor for OS (HR = 1.755, 95% CI 1.311-2.349, P < 0.001).

Conclusions: Elevated RDW may be regarded as an indicator of systemic inflammatory response which might facilitate HC growth and metastasis. Current evidence suggests that RDW may have clinical significance in predicting OS after surgery in HC patients.

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Research Papers:

Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma

Abstract