Clinical Research Papers:
Prevalence of infant sneezing without colds and prediction of childhood allergy diseases in a prospective cohort study
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Abstract
Kuender D. Yang1,2,3,*, Chih-Chiang Wu3,*, Ming-Tsung Lee4, Chia-Yu Ou5, Jen-Chieh Chang6, Chih-Lu Wang5, Hau Chuang6, Ho-Chang Kuo6, Chie-Pein Chen7 and Te-Yao Hsu8
1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
2Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan
3Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
4Research Assistance Center, Show Chwan Memorial Hospital, Changhua, Taiwan
5Department of Pediatrics, Po-Jen Hospital, Kaohsiung, Taiwan
6Department of Pediatrics and Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
7Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Mackay Medical College, Taiwan
8Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Taiwan and Chang Gung University College of Medicine, Kaohsiung, Taiwan
*These authors contributed equally to this work
Correspondence to:
Te-Yao Hsu, email: [email protected]
Ho-Chang Kuo, email: [email protected]
Keywords: asthma; allergic rhinitis; atopic dermatitis; birth cohort; infant sneezing without colds
Received: January 13, 2017 Accepted: October 11, 2017 Published: November 07, 2017
ABSTRACT
Background: Allergy sensitization may begin during the perinatal period, but predicting allergic diseases in infancy remains difficult. This study attempted to identify early predictors of childhood allergy diseases in a prospective cohort study.
Materials and Methods: In a prospective birth cohort study at southern Taiwan locating in a subtropical region, questionnaire surveys of sneezing or cough without colds at 6 and 18 months of age were recorded, and the correlation with allergy diseases was assessed at 3 and 6 years of age.
Results: A total of 1812 pregnant women and 1848 newborn infants were prenatally enrolled, and 1543, 1344, 1236, and 756 children completed the follow-up at ages 6 months, 18 months, 3 years and 6 years, respectively. The prevalence of infant sneezing without colds at 6 and 18 months of age was 30.3% and 19.2%, respectively. The prevalence of infant cough without colds at 6 and 18 months of age was 10.6% and 5.7%, respectively. Infant sneezing without colds at 18 months of age was significantly correlated with atopic dermatitis, allergic rhinitis and asthma at 6 years of age. Infant cough without colds at 18 months of age significantly predicted asthma but not atopic dermatitis or allergic rhinitis at 6 years of age.
Conclusions: Infant sneezing without colds predicted all allergy diseases at 6 years of age in a subtropical country. This highlights a potential non-invasive clue in a subtropical region for the early prediction, treatment and prevention of childhood allergy diseases in infancy.
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