Oncotarget

Research Papers:

miR-217 inhibits laryngeal cancer metastasis by repressing AEG-1 and PD-L1 expression

Susheng Miao, Xionghui Mao, Shu Zhao, Kaibin Song, Cheng Xiang, Yuanjing Lv, Huanyv Jiang, Lei Wang, Baojun Li, Xianguang Yang, Zhennan Yuan, Cheng Xiu, Hongxue Meng and Ji Sun _

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Oncotarget. 2017; 8:62143-62153. https://doi.org/10.18632/oncotarget.19121

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Abstract

Susheng Miao1,*, Xionghui Mao1,*, Shu Zhao3, Kaibin Song1, Cheng Xiang1, Yuanjing Lv1, Huanyv Jiang1, Lei Wang1, Baojun Li1, Xianguang Yang1, Zhennan Yuan1, Cheng Xiu1, Hongxue Meng2 and Ji Sun1

1Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China

2Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China

3Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China

*These authors have contributed equally to the work

Correspondence to:

Hongxue Meng, email: menghongxue15@163.com

Ji Sun, email: drsunji@126.com

Keywords: laryngeal cancer, metastasis, mir-217, AEG-1, PD-L1

Received: September 26, 2016    Accepted: April 14, 2017    Published: July 10, 2017

ABSTRACT

High incidences of laryngeal cancer have been reported recently. Increasing our understanding of the molecular mechanisms underlying this malignancy could reveal more effective approaches to treating laryngeal cancer patients and so improve their prognoses. In this study, we explored the biological effects of miR-217 on laryngeal cancer. miR-217 potently inhibited multiple metastatic traits, including cell migration, invasion, proliferation, apoptosis, and EMT, as well as angiogensis. These effects were achieved through downregulation of the miR-217 target gene, AEG-1 and PD-L1. Clinical expression and animal model studies further confirmed our results. These findings provide new insight into the physiological effects of miR-217 in laryngeal cancer and its potential therapeutic use.


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