Oncotarget

Research Papers:

Association of genetic polymorphisms in IL-1R1 and IL-1R2 genes with IgA nephropathy in the Han Chinese population

Maowei Xie, Daofa Zhang, Yin Zhang, Xiaohong Yang, Yan Su, Yanni Wang, Haiyang Huang, Hui Han, Wenning Li, Keying Fu, Huiluan Su, Wentan Xu and Jiali Wei _

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Oncotarget. 2017; 8:50673-50679. https://doi.org/10.18632/oncotarget.16929

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Abstract

Maowei Xie1,*, Daofa Zhang1,*, Yin Zhang1,*, Xiaohong Yang1, Yan Su1, Yanni Wang1, Haiyang Huang2, Hui Han1, Wenning Li1, Keying Fu2, Huiluan Su1, Wentan Xu1 and Jiali Wei1

1Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China

2Central Laboratory, Hainan General Hospital, Haikou Hainan 570311, China

*These authors contributed equally to this work

Correspondence to:

Jiali Wei, email: wjl525@163.com

Keywords: IgA nephropathy, IL-1R1, IL-1R2, genetics polymorphism, Chinese Han population

Received: February 13, 2017     Accepted: March 23, 2017     Published: April 07, 2017

ABSTRACT

Aim: IgA nephropathy (IgAN) is the major cause of end-stage renal disease(ESRD) in Asia and its pathogenesis is influenced by both genetic and environmental factors. Single nucleotide polymorphisms (SNPs) in IL1R1 and IL-1R2 may be associated with susceptibility to IgAN. In this study, we study the association between genetic variants of IL-1R1 and IL-1R2 and IgA nephropathy risk in the Chinese Han population.

Result: In the allelic model analysis, the rs10490571 and rs3917225 were associated with a 1.40-fold, and 1.31-fold increased risk of IgA nephropathy, respectively. In the genetic model analysis, the rs10490571 in IL1R1 was associated with a 1.46-fold increased risk of IgAN in the dominant model and 1.36-fold increased risk in the Log-additive model, respectively. However, the rs3218977 in IL1R2 was associated with a 0.71-fold decrease risk of IgAN in the dominant model and a 0.71–fold decrease risk in the over-dominant model, respectively. We found four SNPs (rs11674595, rs4851521, rs719250, and rs3218896) constructed four haplotypes in the IL1R2 gene and none of the haplotype was significantly associated with risk of IgAN.

Materials and Methods: A case-control study was conducted including 426 nephropathy patients and 463 healthy controls. Chi-squared tests and genetic model were used to evaluate associations.

Conclusions: These findings suggested that IL-1R1 and IL-1R2 polymorphisms may contribute to the development of IgAN.


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