Oncotarget

Research Papers:

Is FTO gene variant related to cancer risk independently of adiposity? An updated meta-analysis of 129,467 cases and 290,633 controls

Yu Kang, Fang Liu and Yao Liu _

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:50987-50996. https://doi.org/10.18632/oncotarget.16446

Metrics: PDF 613 views  |   HTML 1049 views  |   ?  


Abstract

Yu Kang2, Fang Liu1 and Yao Liu1

1Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China

2Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China

Correspondence to:

Yao Liu, email: swhliuyao@163.com

Keywords: FTO, meta-analysis, cancer, obesity

Received: December 28, 2016     Accepted: February 28, 2017     Published: March 22, 2017

ABSTRACT

Previous studies have examined the association between the fat mass and obesity-associated (FTO) gene variant and risk of cancer in diverse populations. However, the results have been inconsistent. PubMed and Embase databases were searched for the eligible publications in English language by July, 2016. The associations of FTO variants with cancer risk were estimated by calculating the pooled odds ratios and 95% confidence intervals by meta-analyses. A total of 27 publications (129,467 cancer cases and 290,633 normal controls) were included in our meta-analysis. Overall, FTO rs9939609 variant (or its proxy) was not associated with cancer risk without adjustment for body mass index, as well as additional adjustment for body mss index. However, FTO rs9939609 variant was associated with some types of cancer in the subgroup analysis. In addition, overall, there was no significant association between FTO rs1477196 variant and cancer risk regardless of adjustment for body mass index. However, FTO rs11075995 variant risk allele was associated with breast cancer risk without adjustment for body mass index, but the association disappeared with further adjustment for body mass index. This study overall does not support that the FTO variant is associated with cancer risk independently of the adiposity.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 16446