Oncotarget

Research Papers:

Association between rs2853669 in TERT gene and the risk and prognosis of human cancer: a systematic review and meta-analysis

Na Shen _, Yanjun Lu, Xiong Wang, Jing Peng, Yaowu Zhu and Liming Cheng

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Oncotarget. 2017; 8:50864-50872. https://doi.org/10.18632/oncotarget.15140

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Abstract

Na Shen1, Yanjun Lu1, Xiong Wang1, Jing Peng1, Yaowu Zhu1 and Liming Cheng1

1Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Correspondence to:

Liming Cheng, email: chengliming2015@163.com

Keywords: TERTp mutations, rs2853669, risk, prognosis, meta-analysis

Received: November 24, 2016    Accepted: January 09, 2017    Published: February 07, 2017

ABSTRACT

The polymorphism rs2853669 within the promoter of telomerase reverse transcriptase gene (TERTp) has been debated about its role in cancer risk and prognosis. Additionally, several studies report inconsistent results concerning the modifying effect of rs2853669 on the prognostic value of TERTp mutations in cancer patients. Here, we performed this meta-analysis to comprehensively evaluate the role of rs2853669 in the risk and prognosis of human cancer, and further assess its modifying impact on TERTp mutations in the survival of cancer patients. We systematically searched literature via PubMed, Web of Science, and EMBASE through July 2016, and included 22 eligible studies. The overall analysis (64,119 cases and 78,988 controls) demonstrated that rs2853669 did not increase or decrease the overall cancer risk. Subsequent analyses also did not reveal any association between rs2853669 and overall cancer prognosis. However, we identified a modifying effect of rs2853669 on TERTp mutations in that, among cancer patients with TERTp mutations, only those carrying the TT genotype had a poor survival (Hazard ratio = 1.56, 95% confidence interval = 1.06-2.28); subgroup analyses by cancer type also supported these results. In conclusion, our findings suggest that rs2853669 could be important for assessing the prognostic value of TERTp mutations. Future large studies are required to further validate our results.


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