Oncotarget

Research Papers:

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

Koji Shindo _, Jun Yu, Masaya Suenaga, Shahriar Fesharakizadeh, Koji Tamura, Jose Alejandro Navarro Almario, Aaron Brant, Michael Borges, Abdulrehman Siddiqui, Lisa Datta, Christopher L. Wolfgang, Ralph H. Hruban, Alison Patricia Klein and Michael Goggins

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Oncotarget. 2017; 8:50824-50831. https://doi.org/10.18632/oncotarget.15137

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Abstract

Koji Shindo1, Jun Yu1, Masaya Suenaga1, Shahriar Fesharakizadeh1, Koji Tamura1, Jose Alejandro Navarro Almario1, Aaron Brant1, Michael Borges1, Abdulrehman Siddiqui1, Lisa Datta4, Christopher L. Wolfgang2, Ralph H. Hruban1, Alison Patricia Klein3,5 and Michael Goggins1,3,4

1Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

4Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

5Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland, USA

Correspondence to:

Michael Goggins, email: mgoggins@jhmi.edu

Keywords: CEL, CELP, CEL-HYB, pancreatic cancer, chronic pancreatitis

Received: November 14, 2016    Accepted: January 01, 2017    Published: February 07, 2017

ABSTRACT

CEL-HYB is a hybrid allele that arose from a crossover between the 3’ end of the Carboxyl ester lipase (CEL) gene and the nearby CEL pseudogene (CELP) and was recently identified as a risk factor for chronic pancreatitis. Since chronic pancreatitis is a risk factor for the development of pancreatic cancer, we compared the prevalence of the CEL-HYB allele in patients with pancreatic ductal adenocarcinoma to spousal controls and disease controls. The CEL-HYB allele was detected using Sanger and next generation sequencing. There was no significant difference in the prevalence of the CEL-HYB allele between cases with pancreatic ductal adenocarcinoma compared to controls; 2.6% (22/850) vs. 1.8% (18/976) (p=0.35). CEL-HYB carriers were not more likely to report a history of pancreatitis. Patients with pancreatic cancer are not more likely than controls to be carriers of the CEL-HYB allele.


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