Oncotarget

Clinical Research Papers:

Vitamin D status among long-term survivors of testicular cancer

Giuseppe Schepisi _, Silvia De Padova, Emanuela Scarpi, Cristian Lolli, Giorgia Gurioli, Cecilia Menna, Salvatore L. Burgio, Lorena Rossi, Valentina Gallà, Valentina Casadio, Samanta Salvi, Vincenza Conteduca and Ugo De Giorgi

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Oncotarget. 2017; 8:36780-36786. https://doi.org/10.18632/oncotarget.14167

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Abstract

Giuseppe Schepisi1, Silvia De Padova1, Emanuela Scarpi1, Cristian Lolli1, Giorgia Gurioli1, Cecilia Menna1, Salvatore L. Burgio1, Lorena Rossi1, Valentina Gallà1, Valentina Casadio1, Samanta Salvi1, Vincenza Conteduca1 and Ugo De Giorgi1

1Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli, 40 I-47014 Meldola (FC), Italy

Correspondence to:

Giuseppe Schepisi, email: giuseppe.schepisi@irst.emr.it

Keywords: germ cell tumor, testicular cancer survivors, 25-hydroxyvitamin D, testosterone, hypogonadism

Received: September 26, 2016     Accepted: November 08, 2016     Published: December 24, 2016

ABSTRACT

A correlation between disturbances in hormone levels and the onset of metabolic disorders has been reported in long-term survivors of testicular cancer (TC).

We evaluated serum vitamin D levels and other biological parameters in a consecutive series of 61 long-term (≥3 years) unilateral TC survivors with a median a follow-up of 4 years and in a cohort of healthy males. Deficient vitamin D levels were observed in 10 (17%) of the 58 long-term unilateral TC survivors but were not reported in healthy males (p=.019, Fisher test). Median vitamin D levels were 18.6 ug/L in 58 assessable TC survivors and 23.6 ug/L in 40 healthy males (p=.031). In univariate logistic regression analysis, TC diagnosis was associated with inadequate levels of vitamin D (p=.047). Vitamin D levels were lower when follow-up was > 10 years, albeit this difference was not statistically significant (p=.074). Long-term (especially > 10 years) TC survivors may have difficulty maintaining optimal vitamin D levels. Larger studies are needed to better characterize vitamin D status and possible correlations with premature hormonal aging reported in long-term TC survivors.


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