Oncotarget

Research Papers:

Comparison of the expression and function of Lin28A and Lin28B in colon cancer

Tianzhen Wang, Yan He, Yuanyuan Zhu, Mingwei Chen, Mingjiao Weng, Chao Yang, Yan Zhang, Ning Ning, Ran Zhao, Weiwei Yang, Yinji Jin, Jing Li, Riju James Rajkumar Ezakiel Redpath1, Lei Zhang, Xiaoming Jin, Zhaohua Zhong, Fengmin Zhang, Yunwei Wei, Guomin Shen, Dong Wang, Ying Liu, Guangyu Wang and Xiaobo Li _

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Oncotarget. 2016; 7:79605-79616. https://doi.org/10.18632/oncotarget.12869

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Abstract

Tianzhen Wang1,*, Yan He1,*, Yuanyuan Zhu2,*, Mingwei Chen3,*, Mingjiao Weng1, Chao Yang1, Yan Zhang4, Ning Ning5, Ran Zhao1, Weiwei Yang1, Yinji Jin1, Jing Li1, Riju James Rajkumar Ezakiel Redpath1, Lei Zhang1, Xiaoming Jin1, Zhaohua Zhong6, Fengmin Zhang6, Yunwei Wei7, Guomin Shen8, Dong Wang9, Ying Liu4, Guangyu Wang2, Xiaobo Li1,10

1Department of Pathology, Harbin Medical University, Harbin, China

2Department of Gastrointestinal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin, China

3Department of Anatomy, Harbin Medical University, Harbin, China

4Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China

5Department of Gastrointestinal Surgery, International Hospital of Pecking University, Beijing, China

6Department of Microbiology, Harbin Medical University, Harbin, China

7Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, China

8Department of Medical Genetics, Medical College, Henan University of Science and Technology, Luoyang, China

9College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

10The Northern Medicine Translational Center, Heilongjiang Province Academy of Medical Science, Harbin, China

*These authors have contributed equally to this work

Correspondence to:

Xiaobo Li, email: lixiaobo@ems.hrbmu.edu.cn

Guangyu Wang, email: wangguangyu@ems.hrbmu.edu.cn

Ying Liu, email: liuying0223@sohu.com

Keywords: colon cancer, Lin28A, Lin28B

Received: August 04, 2016    Accepted: October 14, 2016    Published: October 25, 2016

ABSTRACT

Lin28A and Lin28B are highly conserved RNA binding proteins with similar structure and functions. Recent studies demonstrated that both of them act as oncogenes and promote cancer progression. However, few researches compared the expression and functions of both oncogenes in human malignant tumors at same time. Additionally, although the expression and role of Lin28B in colon cancer is frequently reported, the expression and functions of Lin28A in colon cancer are largely unknown. In this study, we have systematically evaluated the expressional pattern, mutation status and correlation of both Lin28A and Lin28B in colon cancer tissues for the first time, and compared the roles of Lin28A and Lin28B in the proliferation, migration, invasion and apoptosis of colon cancer cells in vitro. We have showed that they are co-expressed and have functional similarities, however, the molecular mechanisms underlying their similar functions may not be identical. This study contributes to clarify the similarities and differences of Lin28A and Lin28B in colon cancer progression.


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