Oncotarget

Research Papers:

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Ying Peng, Yicheng Qi, Fengjiao Huang, Xinxin Chen, Yulin Zhou, Lei Ye, Weiqing Wang, Guang Ning and Shu Wang _

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Oncotarget. 2016; 7:78680-78687. https://doi.org/10.18632/oncotarget.12019

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Abstract

Ying Peng1,*, Yicheng Qi1,*, Fengjiao Huang1, Xinxin Chen1, Yulin Zhou1, Lei Ye1, Weiqing Wang1, Guang Ning1,2, Shu Wang1

1Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China

2Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200025, China

*These authors have contributed equally to this work

Correspondence to:

Shu Wang, email: shuwang999@hotmail.com

Keywords: Graves’ disease, resistin, neutrophils, T3

Received: May 30, 2016    Accepted: September 01, 2016    Published: September 14, 2016

ABSTRACT

Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves’ disease (GD). We undertaked a controlled, prospective study to explore the serum resistin concentration in GD patients before and after -MMI treatment. In addition, we also investigated the main influencing factor on serum resistin level and discuessed the potential role of serum resistin plays in GD patients. 39 untreated GD (uGD) patients, including 8 males and 31 females, were enrolled in our investigation. All of these patients were prescribed with MMI treatment, in addition to 25 healthy controls. Anthropometric parameters and hormone assessment were measured. Enzyme-linked immunosorbent assay was used to detect serum resistin concentration in different stages of GD patients. Furthermore, neutrophil cell line NB4 with or without T3 treatment to detect the effect of thyroid hormones on resistin expression. The serum resistin level and neutrophil counts in untreated GD patients were significantly declined. And all of these parameters were recovered to normal after MMI treatment in ethyroid GD (eGD) and TRAb-negative conversion (nGD) patients. Resistin concentration exhibited a negative correlation with FT3 and FT4, but a positive correlation with absolute number of neutrophiles in uGD patients, whereas did not correlate with thyroid autoimmune antibodies and BMI. Neutrophile cell line, NB4, produced decreased expression of resistin when stimulated with T3. Our study showed a decrease of serum resistin level in GD patients and we suggested that the serum resistin might primarily secreted from circulating neutrophils and down-regulated by excessive thyroid hormones in GD patients.


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