VOLUME 5 (2014)
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About The Cover
This issue's cover figure comes from Agrawal et al. titled "Sac-1004 reduces lung and lymph node metastasis in B16BL6 foot-pad metastasis mice model" . Part F shows sections of popliteal lymph nodes were immunostained for LYVE-1 and cytokeratin-18 (melanocyte marker).
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Table of Contents
Research Perspectives
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| Oncobiguanides: Paracelsus’ law and nonconventional routes for administering diabetobiguanides for cancer treatment |
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https://doi.org/10.18632/oncotarget.1965
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| 2344-2348 |
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| Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms |
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https://doi.org/10.18632/oncotarget.1946
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| 2349-2354 |
Research Papers
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| Inhibition of BRD4 attenuates tumor cell selfrenewal and suppresses stem cell signaling in MYC driven medulloblastoma |
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https://doi.org/10.18632/oncotarget.1659
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| 2355-2371 |
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| Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma |
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https://doi.org/10.18632/oncotarget.1706
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| 2372-2389 |
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| The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway |
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https://doi.org/10.18632/oncotarget.1235
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| 2390-2403 |
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| Alternative splicing of FBPinteracting repressor coordinates cMyc P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycininduced DNA damage pathway |
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https://doi.org/10.18632/oncotarget.1650
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| 2404-2417 |
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| SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I |
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https://doi.org/10.18632/oncotarget.1411
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| 2418-2427 |
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| Bak and Mcl1 are essential for Temozolomide induced cell death in human glioma |
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https://doi.org/10.18632/oncotarget.1642
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| 2428-2435 |
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| WT1 regulates angiogenesis in Ewing Sarcoma |
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https://doi.org/10.18632/oncotarget.1610
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| 2436-2449 |
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| Enrichment of circulating melanoma cells CMCs using negative selection from patients with metastatic melanoma |
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https://doi.org/10.18632/oncotarget.1683
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| 2450-2461 |
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| YB1 expression promotes epithelialtomesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin |
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https://doi.org/10.18632/oncotarget.1790
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| 2462-2474 |
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| FAAH inhibition enhances anandamide mediated antitumorigenic effects in nonsmall cell lung cancer by downregulating the EGF/EGFR pathway |
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https://doi.org/10.18632/oncotarget.1723
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| 2475-2486 |
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| A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy |
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https://doi.org/10.18632/oncotarget.1740
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| 2487-2498 |
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| A highcontent morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation |
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https://doi.org/10.18632/oncotarget.1703
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| 2499-2512 |
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| miR199a3p displays tumor suppressor functions in papillary thyroid carcinoma |
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https://doi.org/10.18632/oncotarget.1830
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| 2513-2528 |
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| STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth |
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https://doi.org/10.18632/oncotarget.1810
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| 2529-2541 |
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| Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes |
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https://doi.org/10.18632/oncotarget.1833
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| 2542-2550 |
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| ATRX mRNA expression combined with IDH1/2 mutational status and Ki67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples |
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https://doi.org/10.18632/oncotarget.1838
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| 2551-2561 |
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| IGF1R a target of let7b mediates crosstalk between IRS2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma |
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https://doi.org/10.18632/oncotarget.1812
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| 2562-2574 |
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| Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth |
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https://doi.org/10.18632/oncotarget.1842
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| 2575-2587 |
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| Biomarkers of reactive resistance and early disease progression during chemotherapy plus bevacizumab treatment for colorectal carcinoma |
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https://doi.org/10.18632/oncotarget.1811
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| 2588-2595 |
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| HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin11 expression |
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https://doi.org/10.18632/oncotarget.1841
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| 2596-2607 |
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| YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes |
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https://doi.org/10.18632/oncotarget.1844
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| 2608-2621 |
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| Targeting the MUC1C oncoprotein inhibits selfrenewal capacity of breast cancer cells |
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https://doi.org/10.18632/oncotarget.1848
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| 2622-2634 |
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| Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma |
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https://doi.org/10.18632/oncotarget.1862
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| 2635-2647 |
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| Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression |
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https://doi.org/10.18632/oncotarget.1917
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| 2648-2663 |
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| Isorhapontigenin ISO inhibited cell transformation by inducing G0/G1 phase arrest via increasing MKP1 mRNA stability |
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https://doi.org/10.18632/oncotarget.1872
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| 2664-2677 |
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| Sublethal concentrations of 17AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells |
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https://doi.org/10.18632/oncotarget.1929
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| 2678-2687 |
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| Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALKmutated neuroblastoma |
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https://doi.org/10.18632/oncotarget.1883
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| 2688-2702 |
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| Hyperactivation of Alk induces neonatal lethality in knockin AlkF1178L mice |
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https://doi.org/10.18632/oncotarget.1882
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| 2703-2713 |
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| The antiapoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the Nend rule pathway |
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https://doi.org/10.18632/oncotarget.1931
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| 2714-2722 |
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| Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth cell migration and angiogenesis |
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https://doi.org/10.18632/oncotarget.1884
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| 2723-2735 |
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| Tumor cellproduced matrix metalloproteinase 9 MMP9 drives malignant progression and metastasis of basallike triple negative breast cancer |
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https://doi.org/10.18632/oncotarget.1932
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| 2736-2749 |
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| The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target |
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https://doi.org/10.18632/oncotarget.1887
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| 2750-2760 |
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| Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice |
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https://doi.org/10.18632/oncotarget.1942
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| 2761-2777 |
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| Indoleamine 23dioxygenase mediates immuneindependent human tumor cell resistance to olaparib gamma radiation and cisplatin |
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https://doi.org/10.18632/oncotarget.1916
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| 2778-2791 |
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| microRNA148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression |
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https://doi.org/10.18632/oncotarget.1920
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| 2792-2806 |
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| Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells and synergizes with irinotecan |
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https://doi.org/10.18632/oncotarget.1921
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| 2807-2819 |
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| RNA binding protein RBM14 promotes radioresistance in glioblastoma by regulating DNA repair and cell differentiation |
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https://doi.org/10.18632/oncotarget.1924
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| 2820-2826 |
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| ROSinduced epithelialmesenchymal transition in mammary epithelial cells is mediated by NFκBdependent activation of Snail |
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https://doi.org/10.18632/oncotarget.1940
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| 2827-2838 |
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| Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups |
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https://doi.org/10.18632/oncotarget.1943
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| 2839-2852 |
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| Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine a synergistic agent that regulates the ROSmediated signaling |
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https://doi.org/10.18632/oncotarget.1854
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| 2853-2863 |
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